Journal
CELL COMMUNICATION AND SIGNALING
Volume 20, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12964-022-00939-8
Keywords
N6-methyl-adenosine; Innate; Adaptive; Immunity; m(6)A writers; m(6)A erasers; m(6)A readers
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Funding
- Science, Technology & Innovation Funding Authority (STDF)
- Egyptian Knowledge Bank (EKB)
- German Federal Ministry of Education and Research
- Egyptian Science, Technology and Innovation Funding Authority (STDF) through the German Egyptian Research Fund (GERF-REMARK Project) [33603]
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N6-methyl-adenosine (m(6)A) modification plays a crucial role in gene expression regulation and its dysregulation is associated with diseases. In the immune system, m(6)A modification regulates immune cell functions and immune responses.
N6-methyl-adenosine (m(6)A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m(6)A relies on m(6)A writers, erasers and readers. m(6)A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels. The dysregulation of m(6)A modification has been implicated in various human diseases. Thus, m(6)A modification has now become a research hotspot for its potential therapeutic applications in the treatment of various cancers and diseases. The immune system is essential to provide defense against infections and cancers. This review summarizes the current knowledge about the roles of m(6)A in regulating immune cell functions and immune responses.
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