Journal
CELL
Volume 185, Issue 20, Pages 3652-3670Publisher
CELL PRESS
DOI: 10.1016/j.cell.2022.08.026
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Funding
- NIH [CA019014, DE028211, CA163217, CA228172, CA239583, CA232616, AI147060, CA229673, CA022443]
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This review discusses the life cycle of EBV, its impact on host immune responses, and the neoplastic and autoimmune diseases associated with EBV infection.
Epstein-Barr virus (EBV) is a ubiquitous, oncogenic virus that is associated with a number of different human malignancies as well as autoimmune disorders. The expression of EBV viral proteins and non-coding RNAs contribute to EBV-mediated disease pathologies. The virus establishes life-long latency in the human host and is adept at evading host innate and adaptive immune responses. In this review, we discuss the life cycle of EBV, the various functions of EBV-encoded proteins and RNAs, the ability of the virus to activate and evade immune responses, as well as the neoplastic and autoimmune diseases that are associated with EBV infec-tion in the human population.
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