4.7 Review

Mitochondrial calcium and reactive oxygen species in cardiovascular disease

Related references

Note: Only part of the references are listed.
Review Cell Biology

Mitochondrial quality surveillance: mitophagy in cardiovascular health and disease

Rachel Y. Diao et al.

Summary: Mitophagy is a vital quality control pathway in the heart that removes unwanted or dysfunctional mitochondria, preventing damage to proteins and DNA and suppressing inflammation and cell death. Impairments in mitophagy are associated with various diseases.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2022)

Article Cell Biology

Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation

Qun Chen et al.

Summary: Aging-induced endoplasmic reticulum (ER) stress impairs mitochondrial function, which can be improved by attenuating ER stress or inhibiting calpain 1 (CPN1). These interventions can decrease cardiac injury during ischemia-reperfusion in aged hearts.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2022)

Article Biochemistry & Molecular Biology

The molecular mosaic of regulated cell death in the cardiovascular system

Matthew D. Martens et al.

Summary: Cell death is a highly regulated process involving various mechanisms such as apoptosis, necrosis, and pyroptosis, which together form a mosaic in cardiomyocyte cell death. Understanding how these mechanisms interact can aid in the development of effective therapeutics to prevent cell loss and improve quality of life.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2022)

Review Biochemistry & Molecular Biology

The mitochondrial permeability transition: Recent progress and open questions

Paolo Bernardi et al.

Summary: The basis of mitochondrial permeability transition, a Ca2+-dependent permeability increase of the inner membrane, has been successfully defined, and it has been recognized as a regulator of mitochondrial ion homeostasis and a mechanism of cell death. However, there are still controversial mechanisms regarding the permeability transition that require further research for explanation.

FEBS JOURNAL (2022)

Article Cardiac & Cardiovascular Systems

A Glucagon-like Peptide 1 Analog Protects Mitochondria and Attenuates Hypoxia-Reoxygenation Injury in Cultured Cardiomyocytes

Miyuki Kobara et al.

Summary: Research shows that GLP-1 analogs, like exendin-4, can protect mitochondria and improve the expression of mitochondrial quality control factors, reducing myocardial damage caused by hypoxia-reoxygenation.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2022)

Article Cardiac & Cardiovascular Systems

Effects of OP2113 on Myocardial Infarct Size and No Reflow in a Rat Myocardial Ischemia/Reperfusion Model

Wangde Dai et al.

Summary: The study demonstrated that OP2113 is a promising mitochondrial ROS-modulating agent for reducing no-reflow and myocardial infarct size, especially when administered early in the course of infarction. It also showed benefits on reducing no-reflow even when administered relatively late in the course of ischemia.

CARDIOVASCULAR DRUGS AND THERAPY (2022)

Article Multidisciplinary Sciences

Calpain-mediated protein targets in cardiac mitochondria following ischemia-reperfusion

Ling Li et al.

Summary: Calpain 1 activation during ischemia-reperfusion increases cardiac injury by impairing mitochondrial function and triggering the release of cytochrome c and tAIF from mitochondria to the cytosol. Deletion of CPNS1 reduces mitochondrial damage and improves mitochondrial function during ischemia-reperfusion.

SCIENTIFIC REPORTS (2022)

Review Cardiac & Cardiovascular Systems

The role of autophagy in death of cardiomyocytes

Shohei Ikeda et al.

Summary: Autophagy is a cellular process that helps maintain cellular quality control and energy homeostasis by degrading cellular materials through the lysosomes. It can either adaptively help cells survive stressful conditions or mediate cell death during development and stress response. Dysregulation of autophagy can lead to accumulation of autophagosomes, causing cellular dysfunction and death. In the heart, dysregulated autophagy is associated with cardiomyocyte death and cardiac injury.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022)

Article Cardiac & Cardiovascular Systems

Cysteine 202 of cyclophilin D is a site of multiple post-translational modifications and plays a role in cardioprotection

Georgios Amanakis et al.

Summary: The study demonstrates that C202 plays a crucial role in the binding of CypD to PTP, with its oxidation state potentially regulating the opening of mitochondrial permeability transition pore. Mutating C202 reduces ischemia/reperfusion injury, and C202 is found to be S-nitrosylated during ischemic preconditioning.

CARDIOVASCULAR RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

Pharmacological inhibition of the mitochondrial Ca2+ uniporter: Relevance for pathophysiology and human therapy

Katalin Marta et al.

Summary: Mitochondrial Ca2+ uptake is crucial for meeting the fluctuating energy demands of cells and is mediated by the Ca2+ uniporter. Pharmacological manipulation of mtCU is key to understanding its physiological significance, but specific inhibitors have not been identified. Success in developing small molecule mtCU inhibitors is expected to have clinical impact in various diseases.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca2+ Leak

Ting Liu et al.

Summary: Moderate overexpression of mitochondrial Ca2+ uniporter (MCU) in failing hearts improves contractility and beta-adrenergic responses by reducing oxidative stress-induced SR Ca2+ leak. This overexpression also reverses heart failure and inhibits ectopic ventricular arrhythmias.

CIRCULATION RESEARCH (2021)

Article Cell Biology

Monitoring mitochondrial calcium and metabolism in the beating MCU-KO heart

Anna Kosmach et al.

Summary: Optical methods for measuring intracellular ions, such as Ca2+, have revolutionized our understanding of signal transduction; however, their application to intact organs is limited. By developing a method to optically measure mitochondrial Ca2+ and studying its role in cell energetics and death pathways, we can address the complex functions associated with alterations in mitochondrial Ca2+.

CELL REPORTS (2021)

Article Cardiac & Cardiovascular Systems

Cardiac Energy Metabolism in Heart Failure

Gary D. Lopaschuk et al.

Summary: Changes in cardiac energy metabolism are complex and depend on the severity and type of heart failure, as well as the presence of common comorbidities such as obesity and type 2 diabetes. The failing heart experiences an energy deficit due to decreased mitochondrial oxidative capacity, compensated for by increased ATP production from glycolysis. Alterations in mitochondrial ATP production fuels and fatty acid oxidation contribute to the inefficiency of the failing heart, with potential therapeutic targets in energy metabolic pathways to improve cardiac function.

CIRCULATION RESEARCH (2021)

Editorial Material Cardiac & Cardiovascular Systems

Is the Failing Heart Starved of Mitochondrial Calcium?

Joanne F. Garbincius et al.

CIRCULATION RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction

Dan Tong et al.

Summary: The study demonstrated through a mouse model that HFpEF is associated with myocardial mitochondrial dysfunction, and NAD(+) supplementation is considered a promising therapeutic approach.

CIRCULATION RESEARCH (2021)

Review Cardiac & Cardiovascular Systems

Ketone Body Metabolism in the Ischemic Heart

Stephen C. Kolwicz

Summary: Ketone bodies are recognized as an important fuel source in heart failure and a potential aid for endurance exercise performance. However, their use may not be ideal for individuals with coronary artery disease. The role of ketone body metabolism in ischemic and reperfused myocardium remains unclear.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action

Sandrine Lecour et al.

Summary: The researchers proposed a set of standards called IMPACT to improve the evaluation of cardioprotective interventions before entering clinical studies, aiming to increase the likelihood of translating novel cardioprotective interventions into beneficial clinical practice for patients.

BASIC RESEARCH IN CARDIOLOGY (2021)

Article Genetics & Heredity

Homozygous damaging SOD2 variant causes lethal neonatal dilated cardiomyopathy

Rowida Almomani et al.

JOURNAL OF MEDICAL GENETICS (2020)

Article Cardiac & Cardiovascular Systems

MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure

Seulhee Kim et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

Review Cardiac & Cardiovascular Systems

Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death

Tyler M. Bauer et al.

CIRCULATION RESEARCH (2020)

Article Cardiac & Cardiovascular Systems

A 20/20 view of ANT function in mitochondrial biology and necrotic cell death

Michael J. Bround et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration

Nelli Mnatsakanyan et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Letter Cardiac & Cardiovascular Systems

MICU3 Plays an Important Role in Cardiovascular Function

Bao N. Puente et al.

CIRCULATION RESEARCH (2020)

Review Biochemistry & Molecular Biology

Riding the tiger - physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix

Martin D. Brand

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Mitochondrial Ca2+ concentrations in live cells: quantification methods and discrepancies

Celia Fernandez-Sanz et al.

FEBS LETTERS (2019)

Review Chemistry, Multidisciplinary

Aconitases: Non-redox Iron-Sulfur Proteins Sensitive to Reactive Species

Laura Castro et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Article Multidisciplinary Sciences

An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals

Dominique Detaille et al.

PLOS ONE (2019)

Article Multidisciplinary Sciences

Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase

Joe Carroll et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Physiology

FUNDAMENTAL MECHANISMS OF REGULATED CELL DEATH AND IMPLICATIONS FOR HEART DISEASE

Dominic P. Del Re et al.

PHYSIOLOGICAL REVIEWS (2019)

Article Multidisciplinary Sciences

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

Jason Karch et al.

SCIENCE ADVANCES (2019)

Article Cardiac & Cardiovascular Systems

Ryanodine Receptor Glycation Favors Mitochondrial Damage in the Senescent Heart

Marisol Ruiz-Meana et al.

CIRCULATION (2019)

Review Biochemistry & Molecular Biology

Mitochondrial dysfunction and oxidative stress in heart disease

Jessica N. Peoples et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

Article Medicine, Research & Experimental

The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense

Julie L. Horton et al.

JCI INSIGHT (2019)

Article Endocrinology & Metabolism

Voltage-energized calcium-sensitive ATP production by mitochondria

Andrew P. Wescott et al.

NATURE METABOLISM (2019)

Editorial Material Cardiac & Cardiovascular Systems

Raising NAD in Heart Failure Time to Translate?

Matthew A. Walker et al.

CIRCULATION (2018)

Review Cardiac & Cardiovascular Systems

Calcium Signaling and Reactive Oxygen Species in Mitochondria

Edoardo Bertero et al.

CIRCULATION RESEARCH (2018)

Article Cardiac & Cardiovascular Systems

Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure

Swati Dey et al.

CIRCULATION RESEARCH (2018)

Article Biochemistry & Molecular Biology

MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload

Rogerio Faustino Ribeiro Junior et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Cardiac & Cardiovascular Systems

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

Nicolas Diguet et al.

CIRCULATION (2018)

Review Cardiac & Cardiovascular Systems

The potential role and rationale for treatment of heart failure with sodium-glucose co-transporter 2 inhibitors

Javed Butler et al.

EUROPEAN JOURNAL OF HEART FAILURE (2017)

Review Biochemistry & Molecular Biology

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

Hoi-Shan Wong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Cardiac & Cardiovascular Systems

The role of succinate and ROS in reperfusion injury - A critical appraisal

Tatyana N. Andrienko et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2017)

Article Multidisciplinary Sciences

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

Timothy S. Luongo et al.

NATURE (2017)

Article Multidisciplinary Sciences

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

Jiuya He et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Cardiac & Cardiovascular Systems

Novel Mitochondria-Targeting Peptide in Heart Failure Treatment A Randomized, Placebo-Controlled Trial of Elamipretide

Melissa A. Daubert et al.

CIRCULATION-HEART FAILURE (2017)

Article Biochemistry & Molecular Biology

Ca2+ binding to F-ATP synthase β subunit triggers the mitochondrial permeability transition

Valentina Giorgio et al.

EMBO REPORTS (2017)

Review Cardiac & Cardiovascular Systems

Metabolismin cardiomyopathy: every substrate matters

Julia Ritterhoff et al.

CARDIOVASCULAR RESEARCH (2017)

Article Cardiac & Cardiovascular Systems

Resolution of mitochondrial oxidant stress improves aged-cardiovascular performance

Takashi Owada et al.

CORONARY ARTERY DISEASE (2017)

Article Biochemistry & Molecular Biology

Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy

Rui Ni et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Review Biochemistry & Molecular Biology

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

Martin D. Brand

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Cardiac & Cardiovascular Systems

Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease

Aaron L. Sverdlov et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

Article Cell Biology

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure

Alexander G. Nickel et al.

CELL METABOLISM (2015)

Article Biochemistry & Molecular Biology

Subsarcolemmal and interfibrillar mitochondria display distinct superoxide production profiles

C. Crochemore et al.

FREE RADICAL RESEARCH (2015)

Review Cardiac & Cardiovascular Systems

The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury

Andrew P. Halestrap et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter

Kira M. Holmstroem et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Overexpressing superoxide dismutase 2 induces a supernormal cardiac function by enhancing redox-dependent mitochondrial function and metabolic dilation

Patrick T. Kang et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Article Medicine, General & Internal

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

T. -T. Cung et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

Tyler P. Rasmussen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Mitochondrial calcium overload is a key determinant in heart failure

Gaetano Santulli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Cell & Tissue Engineering

The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review

Fatemeh Atashi et al.

STEM CELLS AND DEVELOPMENT (2015)

Article Multidisciplinary Sciences

The mitochondrial uniporter controls fight or flight heart rate increases

Yuejin Wu et al.

NATURE COMMUNICATIONS (2015)

Article Biophysics

Calcium Movement in Cardiac Mitochondria

Liron Boyman et al.

BIOPHYSICAL JOURNAL (2014)

Review Cell Biology

Mitohormesis

Jeanho Yun et al.

CELL METABOLISM (2014)

Article Cardiac & Cardiovascular Systems

Inhibiting Mitochondrial Na+/Ca2+ Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure

Ting Liu et al.

CIRCULATION RESEARCH (2014)

Article Cardiac & Cardiovascular Systems

Oxidative Post-Translational Modifications Develop LONP1 Dysfunction in Pressure Overload Heart Failure

Atsushi Hoshino et al.

CIRCULATION-HEART FAILURE (2014)

Article Cardiac & Cardiovascular Systems

Reduction of Early Reperfusion Injury With the Mitochondria-Targeting Peptide Bendavia

David A. Brown et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2014)

Article Multidisciplinary Sciences

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Edward T. Chouchani et al.

NATURE (2014)

Review Physiology

MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE

Dmitry B. Zorov et al.

PHYSIOLOGICAL REVIEWS (2014)

Article Multidisciplinary Sciences

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

Kambiz N. Alavian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

High Dietary Fat Selectively Increases Catalase Expression within Cardiac Mitochondria

Paul M. Rindler et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Multidisciplinary Sciences

Mitochondrial calcium uptake

George S. B. Williams et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Dimers of mitochondrial ATP synthase form the permeability transition pore

Valentina Giorgio et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics

Brian Glancy et al.

BIOCHEMISTRY (2012)

Review Cardiac & Cardiovascular Systems

Calcium-mediated cell death during myocardial reperfusion

David Garcia-Dorado et al.

CARDIOVASCULAR RESEARCH (2012)

Article Biochemistry & Molecular Biology

Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity

Huali Zhang et al.

FASEB JOURNAL (2012)

Article Biochemistry & Molecular Biology

A Refined Analysis of Superoxide Production by Mitochondrial sn-Glycerol 3-Phosphate Dehydrogenase

Adam L. Orr et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion

Gabriel Loor et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

Review Endocrinology & Metabolism

Glucagon-like peptide-1-based therapies and cardiovascular disease: looking beyond glycaemic control

P. Anagnostis et al.

DIABETES OBESITY & METABOLISM (2011)

Review Biochemistry & Molecular Biology

Mitochondrial consumption of cytosolic ATP: Not so fast

Christos Chinopoulos

FEBS LETTERS (2011)

Review Biochemistry & Molecular Biology

Reactive oxygen species in cardiovascular disease

Koichi Sugamura et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Cardiac & Cardiovascular Systems

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

Dao-Fu Dai et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

Article Multidisciplinary Sciences

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Diego De Stefani et al.

NATURE (2011)

Article Cardiac & Cardiovascular Systems

Adverse Bioenergetic Consequences of Na+-Ca2+ Exchanger-Mediated Ca2+ Influx in Cardiac Myocytes

Michael Kohlhaas et al.

CIRCULATION (2010)

Review Physiology

Myocardial Fatty Acid Metabolism in Health and Disease

Gary D. Lopaschuk et al.

PHYSIOLOGICAL REVIEWS (2010)

Article Multidisciplinary Sciences

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

Raz Palty et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

Robert B. Hamanaka et al.

TRENDS IN BIOCHEMICAL SCIENCES (2010)

Article Cardiac & Cardiovascular Systems

Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria

Kerstin Boengler et al.

BASIC RESEARCH IN CARDIOLOGY (2009)

Review Biochemistry & Molecular Biology

How mitochondria produce reactive oxygen species

Michael P. Murphy

BIOCHEMICAL JOURNAL (2009)

Review Biochemistry & Molecular Biology

Mitochondrial calcium and the permeability transition in cell death

John J. Lemasters et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2009)

Article Cardiac & Cardiovascular Systems

Mitochondrial Ca2+ uptake: Tortoise or hare?

Brian O'Rourke et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes

Tatyana N. Andrienko et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

Editorial Material Cardiac & Cardiovascular Systems

Why did the NHE inhibitor clinical trials fail?

Elizabeth Murphy et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia

Lufang Zhou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)

Article Cardiac & Cardiovascular Systems

Enhancing mitochondrial Ca2+ uptake in myocytes from failing hearts restores energy supply and demand matching

Ting Liu et al.

CIRCULATION RESEARCH (2008)

Article Geriatrics & Gerontology

Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria

Piper M. Treuting et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2008)

Article Medicine, General & Internal

Effect of cyclosporine on reperfusion injury in acute myocardial infarction

Christophe Piot et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Review Cardiac & Cardiovascular Systems

Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia-reperfusion injury

Marisol Ruiz-Meana et al.

CARDIOVASCULAR RESEARCH (2008)

Article Biochemistry & Molecular Biology

Human αB-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice

Namakkal S. Rajasekaran et al.

Article Cardiac & Cardiovascular Systems

Potent mitochondria-targeted peptides reduce myocardial infarction in rats

Janghyun Cho et al.

CORONARY ARTERY DISEASE (2007)

Article Biochemistry & Molecular Biology

Oxidative stress causes heart failure with impaired mitochondrial respiration

Hidetoshi Nojiri et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

VJ Adlam et al.

FASEB JOURNAL (2005)

Article Biochemistry & Molecular Biology

Properties of the permeability transition pore in mitochondria devoid of cyclophilin D

E Basso et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Biochemistry & Molecular Biology

Mitochondria, oxidants, and aging

RS Balaban et al.

Article Cardiac & Cardiovascular Systems

Effect of inhibition of Na+/Ca2+ exchanger at the time of myocardial reperfusion on hypercontracture and cell death

J Inserte et al.

CARDIOVASCULAR RESEARCH (2002)

Article Cardiac & Cardiovascular Systems

Postischemic recovery of contractile function is impaired in SOD2± but not SOD1± mouse hearts

GK Asimakis et al.

CIRCULATION (2002)

Article Cardiac & Cardiovascular Systems

Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis

H Van Remmen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2001)

Article Cardiac & Cardiovascular Systems

Role of the reverse mode of the Na+/Ca2+ exchanger in reoxygenation-induced cardiomyocyte injury

C Schäfer et al.

CARDIOVASCULAR RESEARCH (2001)