☆ 4.3 Review

Amyloid deposition in an explanted bioprosthetic aortic valve: case report and review of the literature

CARDIOVASCULAR PATHOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

Noncalcific Mechanisms of Bioprosthetic Structural Valve Degeneration

Matteo Marro et al.

Summary: Bioprosthetic heart valves (BHVs) offer an alternative to mechanical valves with reduced long-term anticoagulation needs, but are prone to structural valve degeneration which may require reoperation. This degeneration, often characterized by leaflet calcification, can also occur with minimal mineralization in some cases, posing challenges for treatment. Various factors such as protein infiltration, glycation, oxidative and mechanical stress, and inflammation may play a role in noncalcific mechanisms of BHV structural valve degeneration.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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