Journal
CARBOHYDRATE RESEARCH
Volume 521, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2022.108674
Keywords
Alcohol; Carboxylic acid; Glycosylated ester; Trichloroacetimidate
Funding
- Science and Engineering Research Board (SERB) , New Delhi
- [CRG/2021/002776]
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In this study, acetimidates and commercially available trichloroacetonitrile were used to synthesize diverse glycosylated esters with high-to-excellent yields under one-pot mild reaction conditions. The method has notable features such as metal-free condition, easy handling, and broad substrate scope.
Acetimidates, a valuable intermediate has been well explored as versatile synthon in a number of organic transformations particularly as suitable donors in glycosylation reactions. Herein, we explored acetimidates to furnish high-to-excellent yield of diverse glycosylated esters under one-pot mild reaction condition. The commercially available trichloroacetonitrile is implemented for the activation of carboxylic acid via in situ generation of trichloroacetimidate, which was subsequently attacked by sugar alcohols to deliver high-to -excellent yields of desired glycosylated esters. The devised method has some notable features such as metal -free condition, one-pot mild reaction condition, easy-handling, high-to-excellent yields, and broad substrate scope.
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