Journal
CARBOHYDRATE POLYMERS
Volume 295, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119853
Keywords
Chitosan; Ti3C2@AuNRs; Photothermaleffect; NIR-; pH-responsiveness
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Funding
- Henan Provincial Natural Science Foundation of China [202300410475]
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In this study, a remotely multi-responsive chitosan hydrogel was prepared with near-infrared (NIR) responsiveness, pH response, and thermal responsiveness. It showed notable NIR-triggered photo-thermal effect and remotely controllable drug delivery properties.
Remotely multi-responsive chitosan (CS) hydrogels holds great promise in the design of anticancer drug carriers. In this paper, near-infrared (NIR)-/pH-dual responsive CS/beta-GP/Ti(3)C(2)2@AuNRs hybrid hydrogel was prepared based on CS/beta-glycerol phosphate disodium salt (beta-GP) crosslinking system embedded with NIR-responsive Ti3C2@gold nanorods (AuNRs) nanosheets. Excess beta-GP promoted the formation of massive electronegative cavities, which endowed hybrid hydrogels with high drug loading efficiency for electropositive DOX (around 88.5 %). The collapse of chitosan network in acidic medium gave the hybrid hydrogel with distinct pH response. In addition, the distinct temperature increase owing to the strong NIR responsiveness of Ti3C2@AuNRs nano -sheets would accelerate the DOX release dramatically. Therefore, NIR-, pH-and thermal-multi-responsiveness would synergistically endow CS/beta-GP/Ti3C2@AuNRs hybrid hydrogel with notable NIR-triggered photo -thermal effect and remotely controllable drug delivery properties.
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