Journal
CARBOHYDRATE POLYMERS
Volume 291, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119564
Keywords
Human milk oligosaccharides; Enzymatic synthesis; Chemoenzymatic synthesis; Nutrition
Categories
Funding
- National Key Research and Development Program [2018YFA0901700]
- Natural Science Foun-dation of Jiangsu Province [BK20200728]
- National Natural Science Foundation of China [22007049]
- Jiangsu innovation and entrepreneurship doctoral program
Ask authors/readers for more resources
Human milk oligosaccharides (HMOs) are complex glycans that play a critical role in infant health. However, their limited availability hinders their use. This review examines the progress in enzymatic and chemoenzymatic synthesis of HMOs, and discusses the challenges and opportunities in large-scale synthesis of HMOs.
Human milk oligosaccharides (HMOs) are complex glycans that are the third largest solid component in human milk. It has attracted great interest in recent years due to their critical role in boosting infant health. These oligosaccharides play an important role in a variety of physiological processes, such as shaping the infant gut microbiome, preventing pathogenic infections and promoting the development of immune system. However, limited availability of HMOs hampered their use in food and medical areas. Moreover, most of the HMOs are unique to human milk and difficult to isolate. The strategies, chemical synthesis, whole-cell fermentation, and purification from human milk, have their advantages and come with their own challenges. In this review, we examined the remarkable progress that has been made in the enzymatic and chemoenzymatic synthesis of HMOs, and discussed the challenges and opportunities in large-scale synthesis of HMOs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available