Journal
CARBOHYDRATE POLYMERS
Volume 291, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119520
Keywords
Sphingan WL gum; Exopolysaccharide; Hydrogel dressing; Antibacterial activity; pH-responsive
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Funding
- Natural Science Foundation of China [U1805234, 22007013]
- Natural Science Foundation of Fujian Province of China [2019J01264, 2020J05033]
- Program for Innovative Research Team in Science and Technology in Fujian Province University
- 100 Talents Program of Fujian Province, Scientific Research Start-up Fund for High-Level Talents in Fujian Normal University [004828]
- Fujian-Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering [021D039]
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In this study, citric acid crosslinked WL hydrogel films were developed for wound dressing applications. The hydrogels exhibited high water absorption capacity, hydrolytic stability, and good rheological properties.
Sphingan WL gum (WL), a kind of exopolysaccharides, is produced by Sphingomonas sp. WG. In this study, citric acid (CA) crosslinked WL hydrogel films were firstly developed for potential wound dressing application. ATRFTIR and TG results suggested the occurrence of esterification crosslinking. SEM analysis showed that this aided covalent crosslinking could prevent their porous structures from collapsing when swelling. Due to the deprotonation of carboxyl groups, the water absorption capacity of WL-CA hydrogel films increased with the increase of pH (maximum swelling ratio = 38 g/g). The covalent crosslinked swollen WL-CA hydrogels exhibited certain hydrolytic stability, high porosity (> 60%), moderate tissue adhesion, and good rheological property (G ' > G '', G ' up to 2 kPa). WL-CA-CIP hydrogel films loaded with antibiotic ciprofloxacin (CIP) showed sustained drug release properties, long-lasting antibacterial activity, and superior biocompatibility. All the results indicated that WLbased hydrogels were potential candidates for wound dressing applications.
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