Journal
CARBOHYDRATE POLYMERS
Volume 291, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119464
Keywords
Aloe polysaccharide; Colorectal cancer; Mitochondria; Apoptosis; Metabolism
Categories
Funding
- National Natural Science Founda-tion of China [81760660]
- Applied Basic Research Key Project of Yunnan Province [2018FE001 (-123)]
- Applied Basic Research projects of Yunnan Province [2019FA038]
- Natural Science Foundation of Guangdong Province [2020A1515111135]
- Postdoctoral Science Foundation, China [2021M69078]
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This study demonstrates that the purified polysaccharide ABPA1 from AVBEC can induce apoptosis in colorectal cancer cells by regulating the Bax and cytochrome-c mediated mitochondrial pathway. In vivo experiments show that ABPA1 significantly suppresses tumor growth in an orthotopic colon cancer model and has distinct impacts on the mitochondrial metabolism of colorectal cancer cells.
The anti-cancer effects of Aloe vera barbadensis extract C (AVBEC) have been demonstrated in a previous study. However, the specific functional ingredient and mechanism remain undefined. This study aimed to evaluate the function and associated mechanisms of purified polysaccharide (ABPA1) from AVBEC on colorectal cancer. Here, we identify that ABPA1 can induce colorectal cancer apoptosis. In vivo, ABPA1 significantly suppressed tumor growth in an orthotopic colon cancer model. Mechanistically, ABPA1 alters mitochondrial membrane perme-ability by promoting Bax translocation while causing cytochrome-c release, which initiates the caspase cascade reaction. Additionally, we found that ABPA1 exerted distinct impacts on the mitochondrial metabolism of colorectal cancer cells. Our study elucidated the mechanism by which the polysaccharide ABPA1 induces apoptosis in colorectal cancer cells through the regulation of Bax and cytochrome-c mediated mitochondrial pathway, indicating that ABPA1 may be developed as a mitochondrial-targeting anti-cancer drug.
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