Oxidized Bletilla rhizome polysaccharide-based aerogel with synergistic antibiosis and hemostasis for wound healing

Uncontrolled bleeding and infection following trauma remain a clinical challenge. Here, we developed a syn-ergistic hemostatic and antibacterial aerogel dressing based on oxidized Bletilla rhizome polysaccharide Schiff Base (ORBPS) and polyvinyl alcohol (PVA) by using a combined freeze-drying/cross-linking process. Bletilla rhizome polysaccharide (RBP) was extracted by water extraction and alcohol precipitation. RBP contained mannose and glucose in the molar ratio of 2:1 and its molecular weight was 8.2 x 10(5) g/mol. ORBPS was prepared via Schiff base reaction between silver sulfadiazine and oxidized RBP (ORBP), and verified by FTIR and NMR spectra. The resultant ORBPS/PVA aerogel exhibited excellent antibacterial and hemostatic capabilities. The aerogel also showed good liquid absorption capacity and biocompatibility. Full-thickness skin defect ex-periments indicated the aerogel enhanced wound healing by reducing inflammation, promoting angiogenesis, and accelerating epithelialization. Therefore, ORBPS/PVA aerogel may be a potential hemostasis and anti-infection wound dressing.

Automated summary

A synergistic hemostatic and antibacterial aerogel dressing based on oxidized Bletilla rhizome polysaccharide and polyvinyl alcohol has been developed. The aerogel exhibits excellent antibacterial and hemostatic capabilities, and promotes wound healing by reducing inflammation and accelerating epithelialization.