Journal
CARBOHYDRATE POLYMERS
Volume 291, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119558
Keywords
Hydrogel; Black phosphorus; ZnO; Antibacterial; Immunomodulatory; Infected wound healing
Categories
Funding
- Science and Technology Project of Guangdong Province [2020B1111560001]
- Key Areas and Development Program of Guangzhou [202007020006, 202103030003]
- International Science and Technology Cooperation Project of Huangpu District/Guangzhou Development District [2019GH11, 2020GH14]
- Marine Economy Development Project of Department of Natural Resources of Guangdong Province [GDNRC [2022] 039]
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A dextran-based hydrogel loaded with black phosphorus nanosheets and zinc oxide nanoparticles exhibits synergistic antibacterial activity and reduces macrophage polarization, promoting the healing of infected wounds.
Bacterial infection will attack the wound and aggravate inflammation, which is the main reason for the difficulty in wound healing. Here, we reported a dextran-based hydrogel composed of methacrylated gelatin (GelMA) and oxidized dextran (oDex), which loaded with black phosphorus (BP) nanosheets and zinc oxide nanoparticles (ZnO NPs). The hydrogel exhibited synergistic antibacterial activity of photothermal and zinc ions with an irradiation of 808 nm NIR laser. Meanwhile, trace zinc released from the hydrogel reduced polarization of macrophages towards the M2 phenotype. A larger proportion of M2 macrophages secreted anti-inflammatory factors and cytokines to reduce inflammation and facilitate neovascularization. Under the combined treatment of photothermal stimulation and immune factors, more neovascularization and shorter inflammation appeared in infected full-thickness defect wounds of mouse, which greatly accelerated wounds closure. Therefore, the combined treatment of antibacterial activity and anti-inflammatory properties of hydrogel Gel/BP/ZnO + NIR is suggested to be a hopeful approach for chronic wounds.
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