Journal
CANCER CELL
Volume 40, Issue 10, Pages 1092-1094Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2022.09.008
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Increasing glucose catabolism in brown adipose tissue through cold exposure reduces blood glucose and insulin tolerance, thereby decreasing glucose catabolism in tumors and arresting tumor progression, providing a novel approach for metabolism-based cancer therapy.
Seki et al. report in Nature that increasing glucose catabolism in brown adipose tissue by cold exposure lowers blood glucose and insulin tolerance. This systemic effect on body metabolism decreases glucose catabolism in tumors and arrests tumor progression, offering a novel alternative approach for metabolism -based cancer therapy.
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