4.5 Review

The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy

Journal

CANCER AND METASTASIS REVIEWS
Volume 41, Issue 4, Pages 953-963

Publisher

SPRINGER
DOI: 10.1007/s10555-022-10065-z

Keywords

Cancer; Nuclear envelope; Cancer therapeutics; Lamin; Lem-Domain protein; Banf1

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Funding

  1. Centre for Genomics and Personalised Health Industry Partnership Grant
  2. Chenhall Research Award

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This review provides an overview of the potential role and possible applications of inner nuclear membrane proteins in cancer therapeutics.
Despite significant advances in our understanding of tumourigenesis and cancer therapeutics, cancer continues to account for 30% of worldwide deaths. Therefore, there remains an unmet need for the development of cancer therapies to improve patient quality of life and survival outcomes. The inner nuclear membrane has an essential role in cell division, cell signalling, transcription, cell cycle progression, chromosome tethering, cell migration and mitosis. Furthermore, expression of several inner nuclear membrane proteins has been shown to be frequently altered in tumour cells, resulting in the dysregulation of cellular pathways to promote tumourigenesis. However, to date, minimal research has been conducted to investigate how targeting these dysregulated and variably expressed proteins may provide a novel avenue for cancer therapies. In this review, we present an overview of the involvement of the inner nuclear membrane proteins within the hallmarks of cancer and how they may be exploited as potent anti-cancer therapeutics.

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