Electroretinographic findings in retinal vasculitis

Aim To describe and correlate electroretinographic responses with clinical and angiographic findings in retinal vasculitis (RV). Methods Medical records of patients with diagnosis of RV at a tertiary eye centre from December 2017 to May 2021 were reviewed. Cases in which fluorescein angiography (FFA) and full field electroretinography (ffERG) were done within 1 month were included. FFAs were graded according to the Angiography Scoring for Uveitis Working Group from 0 to 40, where 0 is normal. A novel ffERG grading system was implemented where individual waves were graded for timing and amplitude and general ffERG score was determined with 6 being a perfect score. Results 20 patients (34 eyes) were included. Mean age was 43.9 +/- 19.8 years; 70% were female. Median best-corrected visual acuity was 0.8 (0.08-1). Mean FFA score was 12.6 +/- 6.5. Median general ffERG score was 5 (0-6). 68% and 91% of eyes had responses with general ffERG scores >= 5 and 4, respectively. Flicker timing was most commonly affected. FFA scores weakly correlated with delayed photopic cone b-wave and flicker timing (p=0.03 and 0.016, respectively). Vitreous haze moderately correlated with delayed cone b-wave timing (p<0.001), delayed flicker timing (p=0.002) and weakly correlated with lower flicker amplitude (p=0.03). Underlying systemic disease was associated with poor ffERG responses. Conclusion In this study, RV was not frequently associated with severe global retinal dysfunction Higher FFA scores, and vitreous haze grading were weakly, but significantly, correlated with cone-generated ffERG responses.

Automated summary

This study describes and correlates electroretinographic responses with clinical and angiographic findings in patients with retinal vasculitis (RV). The study found weak correlations between high FFA scores and vitreous haze grading and cone-generated ffERG responses.