Journal
BRIEFINGS IN BIOINFORMATICS
Volume 23, Issue 6, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbac386
Keywords
immunotherapy; glioblastoma; lncRNA; immune checkpoint; immune infiltration; prognosis
Funding
- Hunan Provincial Natural Science Foundation of China [2022JJ20095]
- Hunan Provincial Health Committee Foundation of China [202204044869]
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A computational framework was used to identify immune cell-specific long noncoding RNAs (lncRNAs) in glioblastoma (GBM) and develop a signature that could predict survival outcomes and response to immunotherapy. This signature showed superior performance compared to previous signatures and was correlated with immune cell infiltration and immunotherapy response.
Long noncoding ribonucleic acids (RNAs; lncRNAs) have been associated with cancer immunity regulation. However, the roles of immune cell-specific lncRNAs in glioblastoma (GBM) remain largely unknown. In this study, a novel computational framework was constructed to screen the tumor-infiltrating immune cell-associated lncRNAs (TIIClnc) for developing TIIClnc signature by integratively analyzing the transcriptome data of purified immune cells, GBM cell lines and bulk GBM tissues using six machine learning algorithms. As a result, TIIClnc signature could distinguish survival outcomes of GBM patients across four independent datasets, including the Xiangya in-house dataset, and more importantly, showed superior performance than 95 previously established signatures in gliomas. TIIClnc signature was revealed to be an indicator of the infiltration level of immune cells and predicted the response outcomes of immunotherapy. The positive correlation between TIIClnc signature and CD8, PD-1 and PD-L1 was verified in the Xiangya in-house dataset. As a newly demonstrated predictive biomarker, the TIIClnc signature enabled a more precise selection of the GBM population who would benefit from immunotherapy and should be validated and applied in the near future.
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