Journal
BRAZILIAN JOURNAL OF MICROBIOLOGY
Volume 53, Issue 4, Pages 1761-1779Publisher
SPRINGER
DOI: 10.1007/s42770-022-00813-2
Keywords
Meyerozyma guilliermondii; Meyerozyma caribbica; Meyerozyma carpophila; Antifungal; Drug resistance
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Meyerozyma guilliermondii is a microorganism that can cause serious infections and its incidence has increased in recent years. Reduced sensitivity to conventional antifungals and drug resistance have raised concerns among researchers.
Meyerozyma guilliermondii has been accepted as a complex composed of Meyerozyma guilliermondii, Meyerozyma carpophila, and Meyerozyma caribbica. M. guilliermondii is a saprophyte detected on human mucosa and skin. It can lead to serious infections in patients with risk factors like chemotherapy, immunodeficiency, gastrointestinal or cardiovascular surgery, and oncology disorders. Most deaths related to M. guilliermondii infections occur in individuals with malignancy. In recent decades, incidence of M. guilliermondii infections is increased. Sensitivity of this microorganism to conventional antifungals (e.g., amphotericin B, fluconazole, micafungin and anidulafungin) was reduced. Prophylactic and empirical uses of these drugs are linked to elevated minimal inhibitory concentrations (MICs) of M. guilliermondii. Drug resistance has concerned many researchers across the world. They are attempting to discover appropriate solution to combat this challenge. This study reviews the most important mechanisms of resistance to antifungals developed by in M. guilliermondii species complex.
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