4.6 Article

kHz-frequency electrical stimulation selectively activates small, unmyelinated vagus afferents

Related references

Note: Only part of the references are listed.
Article Neurosciences

Excitation properties of computational models of unmyelinated peripheral axons

Nicole A. Pelot et al.

Summary: Biophysically based computational models of nerve fibers are essential for designing stimulation therapies, studying drug effects, and investigating neurological diseases. In this study, a cable model of unmyelinated vagal nerve fibers was developed and compared with existing models, highlighting the need for additional data to improve the modeling of autonomic nerves.

JOURNAL OF NEUROPHYSIOLOGY (2021)

Article Neurosciences

Functional anatomy of the vagus system-Emphasis on the somato-visceral interface

Winfried L. Neuhuber et al.

Summary: The vagus nerve plays a crucial role in autonomic networks and has drawn continuous interest from both basic scientists and clinicians. Recent advancements in vagus nerve stimulation strategies and their applications provide an opportunity to review basic features of vagal peripheral and central anatomy. Beyond the classical vagal brainstem nuclei, other nuclei like the spinal trigeminal and paratrigeminal nuclei also serve as targets for vagal afferents, while the nucleus of the solitary tract integrates visceral and somatic afferents, contributing significantly to the somatovisceral interface.

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2021)

Article Engineering, Biomedical

Bayesian optimization of peripheral intraneural stimulation protocols to evoke distal limb movements

E. Losanno et al.

Summary: The study demonstrates that an algorithm can efficiently adjust peripheral nerve stimulation protocols to aid in the development of motor neuroprostheses for clinical applications. This method was validated in experiments, showing the ability to quickly identify optimal stimulation protocols and evoke functionally consistent movements.

JOURNAL OF NEURAL ENGINEERING (2021)

Article Biochemical Research Methods

Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation

Kirill Aristovich et al.

Summary: Optimized electrical neuromodulation of the cervical vagus nerve can selectively affect respiratory rate or heart rate, revealing organ-specific organization of neural fibers in the cervical vagus nerve.

JOURNAL OF NEUROSCIENCE METHODS (2021)

Article Multidisciplinary Sciences

Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance

Edgar Pena et al.

Summary: The study demonstrates the existence of non-monotonic threshold-frequency relationships between kilohertz frequency and direct current block in nerve conduction. Amplitude- and frequency-dependent charge imbalances play a key role in shifting between different blocking regimes, leading to the potential for selective block of small fiber diameters at lower thresholds. This research reconciles previous contradictory studies and clarifies the mechanisms of interaction between different block regimes.

SCIENTIFIC REPORTS (2021)

Review Clinical Neurology

Kilohertz-frequency stimulation of the nervous system: A review of underlying mechanisms

Clemens Neudorfer et al.

Summary: Electrical stimulation in the kilohertz-frequency range elicits diverse effects on neural tissue, distinct from conventional stimulation, including subthreshold, suprathreshold, synaptic, and thermal effects. These effects offer new therapeutic avenues but are associated with unique challenges and caveats that need to be considered in experimental paradigms.

BRAIN STIMULATION (2021)

Article Multidisciplinary Sciences

Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury

Shinji Tanaka et al.

Summary: The study found that VNS can protect the kidneys from ischemia-reperfusion injury by stimulating vagus nerve fibers and identified the related neural circuits; this is crucial for the clinical application of VNS for protection from acute kidney injury.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Engineering, Biomedical

Implant- and anesthesia-related factors affecting cardiopulmonary threshold intensities for vagus nerve stimulation

Umair Ahmed et al.

Summary: The study found that the threshold for eliciting discernable neural responses with VNS is significantly lower than that for causing a drop in heart rate. Additionally, factors such as implant age, electrode impedance, and type of anesthesia were shown to affect VNS thresholds.

JOURNAL OF NEURAL ENGINEERING (2021)

Article Engineering, Biomedical

In vivo quantification of excitation and kilohertz frequency block of the rat vagus nerve

N. A. Pelot et al.

JOURNAL OF NEURAL ENGINEERING (2020)

Article Multidisciplinary Sciences

The liver-brain-gut neural arc maintains the Treg cell niche in the gut

Toshiaki Teratani et al.

NATURE (2020)

Article Multidisciplinary Sciences

Anodal block permits directional vagus nerve stimulation

Umair Ahmed et al.

Scientific Reports (2020)

Review Immunology

Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation

Harold A. Silverman et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Engineering, Biomedical

Neural activity of functionally different retinal ganglion cells can be robustly modulated by high-rate electrical pulse trains

Madhuvanthi Muralidharan et al.

JOURNAL OF NEURAL ENGINEERING (2020)

Article Engineering, Biomedical

Sources of off-target effects of vagus nerve stimulation using the helical clinical lead in domestic pigs

Evan N. Nicolai et al.

JOURNAL OF NEURAL ENGINEERING (2020)

Article Multidisciplinary Sciences

Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

Pradeep S. Rajendran et al.

NATURE COMMUNICATIONS (2019)

Review Gastroenterology & Hepatology

Bioelectric neuromodulation for gastrointestinal disorders: effectiveness and mechanisms

Sophie C. Payne et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Immunology

Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway

Evilin Naname Komegae et al.

BRAIN BEHAVIOR AND IMMUNITY (2018)

Review Neurosciences

Effects of vagal neuromodulation on feeding behavior

Nicole A. Pelot et al.

BRAIN RESEARCH (2018)

Review Engineering, Biomedical

Challenges associated with nerve conduction block using kilohertz electrical stimulation

Yogi A. Patel et al.

JOURNAL OF NEURAL ENGINEERING (2018)

Article Engineering, Biomedical

First demonstration of velocity selective recording from the pig vagus using a nerve cuff shows respiration afferents

B. W. Metcalfe et al.

BIOMEDICAL ENGINEERING LETTERS (2018)

Article Surgery

Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action

Helene Johannessen et al.

OBESITY SURGERY (2017)

Review Gastroenterology & Hepatology

The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation

Kirsteen N. Browning et al.

GASTROENTEROLOGY (2017)

Article Engineering, Biomedical

Kilohertz Electrical Stimulation Nerve Conduction Block: Effects of Electrode Surface Area

Yogi A. Patel et al.

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (2017)

Review Immunology

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

Sangeeta S. Chavan et al.

IMMUNITY (2017)

Review Cardiac & Cardiovascular Systems

Baroreflex activation therapy: a new approach to the management of advanced heart failure with reduced ejection fraction

Edoardo Gronda et al.

JOURNAL OF CARDIOVASCULAR MEDICINE (2017)

Article Engineering, Biomedical

Modeling the response of small myelinated axons in a compound nerve to kilohertz frequency signals

N. A. Pelot et al.

JOURNAL OF NEURAL ENGINEERING (2017)

Review Medicine, General & Internal

Plasticity of vagal afferent signaling in the gut

Gintautas Grabauskas et al.

MEDICINA-LITHUANIA (2017)

Review Medicine, General & Internal

Plasticity of vagal afferent signaling in the gut

Gintautas Grabauskas et al.

MEDICINA-LITHUANIA (2017)

Article Cardiac & Cardiovascular Systems

Cervical vagus nerve stimulation augments spontaneous discharge in second- and higher-order sensory neurons in the rat nucleus of the solitary tract

Eric Beaumont et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

Review Clinical Neurology

Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part I

Hsiangkuo Yuan et al.

HEADACHE (2016)

Review Neurosciences

Role of the vagus nerve in the development and treatment of diet-induced obesity

Guillaume de Lartigue

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Article Cardiac & Cardiovascular Systems

Vagus Nerve Stimulation for the Treatment of Heart Failure The INOVATE-HF Trial

Michael R. Gold et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)

Editorial Material Surgery

American Society for Metabolic and Bariatric Surgery position statement on vagal blocking therapy for obesity

Pavlos Papasavas et al.

SURGERY FOR OBESITY AND RELATED DISEASES (2016)

Article Education, Scientific Disciplines

Neural control of the immune system

Eva Sundman et al.

ADVANCES IN PHYSIOLOGY EDUCATION (2014)

Review Medicine, Research & Experimental

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

Kevin L. Kilgore et al.

NEUROMODULATION (2014)

Article Engineering, Biomedical

High-resolution measurement of electrically-evoked vagus nerve activity in the anesthetized dog

Paul B. Yoo et al.

JOURNAL OF NEURAL ENGINEERING (2013)

Article Engineering, Biomedical

High-Frequency Stimulation Selectively Blocks Different Types of Fibers in Frog Sciatic Nerve

Laveeta Joseph et al.

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (2011)

Article Biochemical Research Methods

Neural electrode degradation from continuous electrical stimulation: Comparison of sputtered and activated iridium oxide

Sandeep Negi et al.

JOURNAL OF NEUROSCIENCE METHODS (2010)

Review Neurosciences

Pyramidal neurons: dendritic structure and synaptic integration

Nelson Spruston

NATURE REVIEWS NEUROSCIENCE (2008)

Article Neurosciences

Induction of c-fos and ΔFosB immunoreactivity in rat brain by vagal nerve stimulation

J. Thomas Cunningham et al.

NEUROPSYCHOPHARMACOLOGY (2008)

Article Endocrinology & Metabolism

Weight loss during chronic, cervical vagus nerve stimulation in depressed patients with obesity: an observation

J. V. Pardo et al.

INTERNATIONAL JOURNAL OF OBESITY (2007)

Article Mathematical & Computational Biology

Simulation of high-frequency sinusoidal electrical block of mammalian myelinated axons

Niloy Bhadra et al.

JOURNAL OF COMPUTATIONAL NEUROSCIENCE (2007)

Review Physiology

Central pathways of pulmonary and lower airway vagal afferents

Leszek Kubin et al.

JOURNAL OF APPLIED PHYSIOLOGY (2006)

Article Computer Science, Interdisciplinary Applications

Nerve conduction block utilising high-frequency alternating current

KL Kilgore et al.

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING (2004)

Article Engineering, Biomedical

Direct current electrical conduction block of peripheral nerve

N Bhadra et al.

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (2004)

Article Neurosciences

Propagation of action potentials in dendrites depends on dendritic morphology

P Vetter et al.

JOURNAL OF NEUROPHYSIOLOGY (2001)

Article Neurosciences

Functional and chemical anatomy of the afferent vagal system

HR Berthoud et al.

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2000)