Journal
JOURNAL OF HEMATOLOGY & ONCOLOGY
Volume 9, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13045-016-0265-2
Keywords
Unmanipulated haploidentical stem cell transplantation; Donor; Donor-specific anti-human leukocyte antigen antibody; Natural killer alloreactivity; Age; Non-inherited maternal antigen mismatch
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Funding
- National High Technology Research and Development Program of China (Program 863) [2013AA020401]
- Milstein Medical Asian American Partnership Foundation
- Key Program of the National Natural Science Foundation of China [81230013]
- Scientific Research Foundation for Capital Medicine Development [2011-4022-08]
- National Cancer Institute of the National Institutes of Health, USA [CA 015396]
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In haploidentical stem cell transplantations (haplo-SCT), nearly all patients have more than one donor. A key issue in the haplo-SCT setting is the search for the best donor, because donor selection can significantly impact the incidences of acute and chronic graft-versus-host disease, transplant-related mortality, and relapse, in addition to overall survival. In this review, we focused on factors associated with transplant outcomes following unmanipulated haplo-SCT with anti-thymocyte globulin (ATG) or after T-cell-replete haplo-SCT with post-transplantation cyclophosphamide (PT/Cy). We summarized the effects of the primary factors, including donor-specific antibodies against human leukocyte antigens (HLA); donor age and gender; killer immunoglobulin-like receptor-ligand mismatches; and non-inherited maternal antigen mismatches. We also offered some expert recommendations and proposed an algorithm for selecting donors for unmanipulated haplo-SCT with ATG and for T-cell-replete haplo-SCT with PT/Cy.
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