Intact finger representation within primary sensorimotor cortex of musician's dystonia

Sadnicka et al. counter the idea that task-specific dystonia is the result of a disordered hand somatotopy in S1. They suggest that the representational geometry of finger maps is intact and that task-specific dystonia is instead caused by a higher-order disruption of skill encoding. Musician's dystonia presents with a persistent deterioration of motor control during musical performance. A predominant hypothesis has been that this is underpinned by maladaptive neural changes to the somatotopic organization of finger representations within primary somatosensory cortex. Here, we tested this hypothesis by investigating the finger-specific activity patterns in the primary somatosensory and motor cortex using functional MRI and multivariate pattern analysis in nine musicians with dystonia and nine healthy musicians. A purpose-built keyboard device allowed characterization of activity patterns elicited during passive extension and active finger presses of individual fingers. We analysed the data using both traditional spatial analysis and state-of-the art multivariate analyses. Our analysis reveals that digit representations in musicians were poorly captured by spatial analyses. An optimized spatial metric found clear somatotopy but no difference in the spatial geometry between fingers with dystonia. Representational similarity analysis was confirmed as a more reliable technique than all spatial metrics evaluated. Significantly, the dissimilarity architecture was equivalent for musicians with and without dystonia. No expansion or spatial shift of digit representation maps were found in the symptomatic group. Our results therefore indicate that the neural representation of generic finger maps in primary sensorimotor cortex is intact in musician's dystonia. These results speak against the idea that task-specific dystonia is associated with a distorted hand somatotopy and lend weight to an alternative hypothesis that task-specific dystonia is due to a higher-order disruption of skill encoding. Such a formulation can better explain the task-specific deficit and offers alternative inroads for therapeutic interventions.

Automated summary

Sadnicka et al. challenge the notion that task-specific dystonia stems from disrupted hand somatotopy in S1. Instead, they propose that task-specific dystonia is caused by a higher-order disturbance in skill encoding. Through functional MRI and multivariate pattern analysis, they found that finger representations in musicians with dystonia were intact, further supporting the alternative hypothesis.