4.6 Article

Osteoimmunology in periodontitis; a paradigm for Th17/IL-17 inflammatory bone loss

Journal

BONE
Volume 163, Issue -, Pages -

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2022.116500

Keywords

Osteoimmunology; Periodontitis; Th17 cells; Oral microbiome; Bone loss

Funding

  1. intramural programs of NIH/NIDCR

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This review focuses on the mechanisms of induction, amplification, and pathogenicity of Th17 cells in periodontitis.
Periodontitis is a prevalent human disease of inflammation-induced bone destruction. Through studies in patient lesions of rare and common forms of periodontitis and animal model experimentation, Th17/IL-17 related im-mune pathways have emerged as mediators of disease pathology. In this focused review, we examine mecha-nisms of induction, amplification and pathogenicity of Th17 cells in periodontitis.

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