Journal
BMC NEUROLOGY
Volume 22, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12883-022-02891-z
Keywords
Lymphocytic hypophysitis; Autoimmune hypophysitis; Autoimmune hypothalamitis; Cognitive dysfunction; Memory impairment
Categories
Funding
- Zikei Institute of Psychiatry
Ask authors/readers for more resources
Autoimmune hypothalamitis is a rare neuroendocrine disorder that may be associated with autoimmune hypophysitis, but it is uncertain if they are consecutive diseases. This case presents the development of autoimmune hypothalamitis after central diabetes insipidus, with partial improvement through treatment.
Background Autoimmune hypothalamitis is a very rare neuroendocrine disorder that causes central diabetes insipidus, headache, visual impairment, and sometimes cognitive impairment. Autoimmune hypothalamitis may occur in association with autoimmune hypophysitis, including lymphocytic hypophysitis, or in isolation. It is not known whether autoimmune hypothalamitis and autoimmune hypophysitis are consecutive diseases. Case presentation A 52-year-old woman developed autoimmune hypothalamitis 7 years after developing central diabetes insipidus due to lymphocytic hypophysitis, resulting in severe memory impairment. High-dose intravenous methylprednisolone therapy improved her cognitive function and decreased the size of the lesion. Conclusion This case presented a unique clinical course, with a long period of time between the onset of autoimmune hypopituitaritis and the development of autoimmune hypothalamitis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available