4.7 Article

High-throughput microarray reveals the epitranscriptome-wide landscape of m6A-modified circRNA in oral squamous cell carcinoma

Related references

Note: Only part of the references are listed.
Article Dentistry, Oral Surgery & Medicine

Hsa_circ_0009128 mediates progression of oral squamous cell carcinoma by influencing MMP9

Hong Zhang et al.

Summary: This study investigated the role and mechanism of a abnormally expressed circular RNA (hsa_circ_0009128) in oral squamous cell carcinoma (OSCC) progression. The results showed that hsa_circ_0009128 was upregulated in OSCC tissues and cell lines, and correlated with advanced TNM stage and lymph node metastasis. Knockdown of hsa_circ_0009128 inhibited cell proliferation and migration, and decreased EMT in OSCC cells. These findings suggest that hsa_circ_0009128 may play an important role in the malignant progression of OSCC by targeting MMP9 to activate EMT.

ORAL DISEASES (2023)

Article Cell Biology

Circular RNA circFOXO3 regulates KDM2A by targeting miR-214 to promote tumor growth and metastasis in oral squamous cell carcinoma

Yilong Ai et al.

Summary: The study demonstrates that circFOXO3 promotes tumor progression in oral squamous cell carcinoma by sponging miR-214 to up-regulate the expression of KDM2A.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Article Oncology

circIGHG-Induced Epithelial-to-Mesenchymal Transition Promotes Oral Squamous Cell Carcinoma Progression via miR-142-5p/IGF2BP3 Signaling

Jingpeng Liu et al.

Summary: The study identified a unique circRNA, circIGHG, which is significantly upregulated in oral squamous cell carcinoma (OSCC) and associated with poor prognosis. It promotes OSCC invasion and metastasis by interacting with miR-142-5p and IGF2BP3, with epithelial-mesenchymal transition being the main mechanism. These findings suggest that circIGHG could serve as a biomarker and therapeutic target for early diagnosis and treatment of OSCC.

CANCER RESEARCH (2021)

Review Oncology

Radiotherapy and Immunotherapy for Head and Neck Cancer: Current Evidence and Challenges

Jack M. Qian et al.

Summary: Immune checkpoint inhibitors have greatly impacted cancer treatment, but response rates to monotherapy in head and neck squamous cell carcinoma patients are low. There is increasing interest in the potential synergy between radiotherapy and immunotherapy, focusing on enhancing the anti-tumor immune response and improving tumor response to radiation in the field. It is important to consider current challenges and future directions in the emerging field of radioimmunotherapy.

FRONTIERS IN ONCOLOGY (2021)

Review Oncology

m6A Modification in Non-Coding RNA: The Role in Cancer Drug Resistance

Chen Chen et al.

Summary: Cancer drug resistance is a major challenge in therapy, and studies have shown that m6A modification of non-coding RNA plays a crucial role in this process. This modification can control the fate and metabolism of RNA by regulating their stability, subcellular localization, or translation, and plays multiple roles in multiple drug-resistant cancer cells.

FRONTIERS IN ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions

Xin Wang et al.

Summary: N-6-methyladenosine (m(6)A) and circular RNAs (circRNAs) are important players in eukaryotic RNA regulation, with critical roles in cellular and disease processes. Recent research has focused on exploring the crosstalk between m(6)A and circRNAs, with future research directions also being a topic of interest.

MOLECULAR CANCER (2021)

Article Medicine, Research & Experimental

N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization

Chen Chen et al.

Summary: A novel circRNA, circ1662, was found to be highly expressed in CRC tissues and correlated with poor prognosis and tumor depth. Functionally, circ1662 promoted CRC cell invasion and migration by controlling EMT and accelerating YAP1 nuclear accumulation to regulate the SMAD3 pathway.METTL3 induced circ1662 expression and played a role in CRC metastasis.

THERANOSTICS (2021)

Article Biochemistry & Molecular Biology

KEGG: integrating viruses and cellular organisms

Minoru Kanehisa et al.

Summary: KEGG is a curated resource integrating eighteen databases categorized into systems, genomic, chemical and health information, providing mapping tools for understanding cellular and organism-level functions from genome sequences and other molecular datasets. The network variation maps in the KEGG database show how different pathogens and environmental factors influence cellular signaling pathways.

NUCLEIC ACIDS RESEARCH (2021)

Review Dentistry, Oral Surgery & Medicine

Current Role of Radiotherapy in the Management of Oral Cavity Squamous Cell Carcinoma

William M. Mendenhall et al.

Summary: The primary role of radiotherapy in the management of oral cavity SCC is in the postoperative setting, with palliative radiotherapy being reserved for patients with very advanced disease. The likelihood of cure varies depending on the extent of disease, and treatment may include surgery, radiotherapy, chemotherapy, or supportive care.

CRANIOMAXILLOFACIAL TRAUMA & RECONSTRUCTION (2021)

Article Oncology

CircRNA HIPK3 promotes the progression of oral squamous cell carcinoma through upregulation of the NUPR1/PI3K/AKT pathway by sponging miR-637

Weipeng Jiang et al.

Summary: The study revealed that circHIPK3 is upregulated in oral squamous cell carcinoma, promoting cell migration and proliferation while inhibiting apoptosis. It may mediate tumor progression through the miR-637-mediated NUPR1/PI3K/AKT axis.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Biochemistry & Molecular Biology

Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop

Wei Zhao et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Medicine, Research & Experimental

Epigenetic Regulation of m6A Modifications in Human Cancer

Wei Zhao et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Article Cell Biology

Modulation of circRNA Metabolism by m6A Modification

Gaia Di Timoteo et al.

CELL REPORTS (2020)

Article Medicine, Research & Experimental

METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification

Wei Zhao et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Article Biotechnology & Applied Microbiology

METTL3 Promotes Tumorigenesis and Metastasis through BMI1 m6A Methylation in Oral Squamous Cell Carcinoma

Lin Liu et al.

MOLECULAR THERAPY (2020)

Review Medicine, Research & Experimental

Emerging Epigenetic Regulation of Circular RNAs in Human Cancer

Jie Wu et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Review Biochemistry & Molecular Biology

Toward understanding the origin and evolution of cellular organisms

Minoru Kanehisa

PROTEIN SCIENCE (2019)

Article Biochemistry & Molecular Biology

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

Ivano Legnini et al.

MOLECULAR CELL (2017)

Article Biochemistry & Molecular Biology

KEGG: Kyoto Encyclopedia of Genes and Genomes

M Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2000)