4.7 Article

Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

TGFβ-Directed Therapeutics: 2020

Beverly A. Teicher

Summary: The TGFS pathway plays a crucial role in cancer and has the potential to be a therapeutic target. Various drugs are currently in clinical development, but the challenge lies in effectively incorporating these drugs to improve treatment outcomes.

PHARMACOLOGY & THERAPEUTICS (2021)

Article Hematology

Phase II study of single-agent nivolumab in patients with myelofibrosis

Iman Abou Dalle et al.

Summary: Dysregulated JAK-STAT signaling in myelofibrosis induces pro-inflammatory cytokines, suppressing T cell proliferation and differentiation, likely responsible for disease progression. The PD-1 pathway, a therapeutic target in myeloid malignancies, did not show significant efficacy when treated with single-agent nivolumab in the clinical study.

ANNALS OF HEMATOLOGY (2021)

Article Medicine, Research & Experimental

TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis

Lilian Varricchio et al.

Summary: Myelofibrosis is characterized by hyperactivation of JAK/STAT signaling and dysregulation of GATA1 in megakaryocytes. This study demonstrates that AVID200, a TGF-beta 1/3 protein trap, can block excessive TGF-beta signaling and have positive effects on progenitor cells in myelofibrosis.

JCI INSIGHT (2021)

Review Immunology

Regulatory T Cells and Human Disease

Shimon Sakaguchi et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

Article Cell Biology

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

Alessandra Metelli et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Article Oncology

Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation In Vivo

Brittany Woods et al.

CLINICAL CANCER RESEARCH (2019)

Article Mathematical & Computational Biology

PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data

Oscar Franzen et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2019)

Article Immunology

SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-β signaling

Linjia Jiang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Article Cell Biology

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Alessandro Prestipino et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Review Cell Biology

Regulatory T cells in cancer immunotherapy

Atsushi Tanaka et al.

CELL RESEARCH (2017)

Article Multidisciplinary Sciences

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

Julie Stockis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Medicine, Research & Experimental

Efficacy of ALK5 inhibition in myelofibrosis

Lanzhu Yue et al.

JCI INSIGHT (2017)

Article Immunology

Platelets subvert T cell immunity against cancer via GARP-TGFβ axis

Saleh Rachidi et al.

SCIENCE IMMUNOLOGY (2017)

Article Biochemistry & Molecular Biology

Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition

Qiang Jeremy Wen et al.

NATURE MEDICINE (2015)

Review Oncology

Oncogenic Drivers in Myeloproliferative Neoplasms: From JAK2 to Calreticulin Mutations

Xavier Cahu et al.

CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2015)

Article Biochemistry & Molecular Biology

The Molecular Signatures Database Hallmark Gene Set Collection

Arthur Liberzon et al.

CELL SYSTEMS (2015)

Letter Oncology

Anti-transforming growth factor-β therapy in patients with myelofibrosis

John Mascarenhas et al.

LEUKEMIA & LYMPHOMA (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Immunology

TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy

Fabienne Brenet et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Article Medicine, General & Internal

A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis

Srdan Verstovsek et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis

Claire Harrison et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Biochemistry & Molecular Biology

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

Satoshi Yamazaki et al.

Article Hematology

Outcome of Transplantation for Myelofibrosis

Karen K. Ballen et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2010)

Article Immunology

Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg

Julie Stockis et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2009)

Article Immunology

Comparison of stable human Treg and Th clones by transcriptional profiling

Julie Stockis et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2009)

Article Multidisciplinary Sciences

Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras

Noriko Komatsu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Medicine, General & Internal

MPLW515L is anovel somatic activating mutation in myelofibrosis with myeloid metaplasia

Yana Pikman et al.

PLOS MEDICINE (2006)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)