Recent developments in promiscuous enzymatic reactions for carbon-nitrogen bond formation

Biocatalytic promiscuity is a new field of enzyme application in biochemistry, which has received much attention and has developed rapidly in recent years. The promiscuous biocatalysis has been promoted as a useful sup-plement to traditional strategy for the formation of C-heteroatom bonds. The generation of carbon-nitrogen (C-N) bonds is an important issue in synthetic chemistry and is indispensable for the manufacturing of various pharmaceuticals and agrochemicals. Therefore, numerous efficient and reliable synthetic methods for the for-mation of C-N bonds have been developed in recent years. Enzymatic C-N bond forming reactions catalyzed by lipases, cytochrome P450 monooxygenases, glycosyltransferases, amine dehydrogenases, proteases, acylases, amylases and halohydrin dehalogenases are well established for synthetic purposes. This review introduces the recent progress in the construction of C-N bonds using promiscuous enzymes.

Automated summary

Biocatalytic promiscuity, a rapidly developing field in biochemistry, offers an alternative strategy for the formation of C-N bonds, which are crucial for the production of various pharmaceuticals and agrochemicals. This review focuses on recent progress in utilizing promiscuous enzymes for constructing C-N bonds.