4.3 Article

Lactoferrin: from the structure to the functional orchestration of iron homeostasis

Related references

Note: Only part of the references are listed.
Article Nutrition & Dietetics

Lactoferrin Induces Erythropoietin Synthesis and Rescues Cognitive Functions in the Offspring of Rats Subjected to Prenatal Hypoxia

Alexey Sokolov et al.

Summary: The protective effects of apo-rhLF on the cognitive functions of rat offspring subjected to prenatal hypoxia have been analyzed. The results showed that apo-rhLF can rescue cognitive deficits caused by prenatal hypoxia and improve memory.

NUTRIENTS (2022)

Article Critical Care Medicine

Bovine Lactoferrin Alleviates Pulmonary Lipid Peroxidation and Inflammatory Damage in Heat Stroke Rats

Xinyu Xia et al.

Summary: This study found that preadministration of bovine lactoferrin could alleviate lung injury in rats with heat stroke (HS) by delaying the onset of HS, improving survival rate, reducing serum inflammatory response, and alleviating pulmonary oxidative stress damage.

THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT (2022)

Article Nutrition & Dietetics

Dose-Dependent Neuroprotective Effects of Bovine Lactoferrin Following Neonatal Hypoxia-Ischemia in the Immature Rat Brain

Eduardo Sanches et al.

Summary: This study demonstrates that lactoferrin (Lf) supplementation attenuates acute and long-term cerebral injuries caused by hypoxia-ischemia in a dose-dependent manner. The optimal dose of 1 g/kg of Lf showed the best effects, reducing brain volume decreases and other detrimental effects. The research emphasizes the need for better understanding of Lf's effects and potential harmful effects on immature brains.

NUTRIENTS (2021)

Review Biochemistry & Molecular Biology

Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis

Elizabeta Nemeth et al.

Summary: Iron regulation in organisms is primarily controlled by the interaction of the iron-regulatory peptide hormone hepcidin and its receptor ferroportin, which plays a crucial role in maintaining iron homeostasis. Dysregulation of hepcidin can lead to iron overload disorders or iron deficiency, affecting iron delivery and compensatory erythropoiesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Lactoferrin for Prevention and Treatment of Anemia and Inflammation in Pregnant Women: A Comprehensive Review

Jolanta Artym et al.

Summary: Pregnancy requires higher levels of nutrients, including iron, for the growth and maintenance of the fetus. Iron deficiency during pregnancy can lead to serious health issues, making iron supplementation essential for pregnant women. Studies suggest that lactoferrin can be an effective prophylaxis and treatment for iron deficiency anemia during pregnancy, offering various beneficial effects on iron homeostasis and overall health.

BIOMEDICINES (2021)

Article Medicine, Research & Experimental

Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer

Zheng Zhang et al.

Summary: The study showed that iron-saturated Lactoferrin (Holo-Lf) can induce ferroptosis in triple-negative breast cancer cells and enhance their sensitivity to radiotherapy. Conversely, low iron-saturated Lactoferrin (Apo-Lf) may inhibit this cell death process. Non-triple-negative breast cancer cells may have resistance to Holo-Lf-induced ferroptosis due to higher redox balance capacity.

THERANOSTICS (2021)

Review Obstetrics & Gynecology

Iron deficiency in pregnancy

Michael K. Georgieff

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2020)

Review Biochemistry & Molecular Biology

Viral Hepatitis and Iron Dysregulation: Molecular Pathways and the Role of Lactoferrin

Romina Mancinelli et al.

MOLECULES (2020)

Review Biochemistry & Molecular Biology

Lactoferrin's Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action

Antimo Cutone et al.

BIOMOLECULES (2020)

Article Multidisciplinary Sciences

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

Christian B. Billesbolle et al.

NATURE (2020)

Article Obstetrics & Gynecology

Polish Society of Gynecologists and Obstetricians recommendations on supplementation during pregnancy

Mariusz Zimmer et al.

GINEKOLOGIA POLSKA (2020)

Article Medicine, Research & Experimental

Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy

Allison L. Fisher et al.

JCI INSIGHT (2020)

Article Medicine, Research & Experimental

A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway

Waleed A. Mohamed et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Biochemistry & Molecular Biology

Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice

Shuang-Feng Xu et al.

REDOX BIOLOGY (2019)

Article Nutrition & Dietetics

The Benefits and Risks of Iron Supplementation in Pregnancy and Childhood

Michael K. Georgieff et al.

Annual Review of Nutrition (2019)

Review Biochemistry & Molecular Biology

Lactoferrin in Aseptic and Septic Inflammation

Maria Stefania Lepanto et al.

MOLECULES (2019)

Article Nutrition & Dietetics

Lactoferrin in Human Milk of Prolonged Lactation

Matylda Czosnykowska-Lukacka et al.

NUTRIENTS (2019)

Review Hematology

Anemia of inflammation

Guenter Weiss et al.

BLOOD (2019)

Review Chemistry, Medicinal

Iron in Lung Pathology

Vida Zhang et al.

PHARMACEUTICALS (2019)

Review Chemistry, Medicinal

Iron Supplementation Therapy, A Friend and Foe of Mycobacterial Infections?

Rafiou Agoro et al.

PHARMACEUTICALS (2019)

Article Biochemistry & Molecular Biology

Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin

E. T. Zakharova et al.

BIOMETALS (2018)

Article Biochemistry & Molecular Biology

Role of lactoferrin and its receptors on biliary epithelium

Romina Mancinelli et al.

BIOMETALS (2018)

Article Biochemistry & Molecular Biology

The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin

Maria Carmela Bonaccorsi di Patti et al.

BIOMETALS (2018)

Article Hematology

Hepcidin agonists as therapeutic tools

Carla Casu et al.

BLOOD (2018)

Review Pharmacology & Pharmacy

Lactoferrin and Peptide-derivatives: Antimicrobial Agents with Potential Use in Nonspecific Immunity Modulation

Maria Elisa Drago-Serrano et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

Article Biochemistry & Molecular Biology

Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism

Yashuo Zhao et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Biochemistry & Molecular Biology

Inflammation-induced iron transport and metabolism by brain microglia

Ryan C. McCarthy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Neurosciences

Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage

Zhen Zhang et al.

MOLECULAR NEUROBIOLOGY (2017)

Review Biochemistry & Molecular Biology

Role of iron in the pathogenesis of respiratory disease

Md Khadem Ali et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis

Luigi Rosa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Biochemistry & Molecular Biology

Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia

Pamela J. Urrutia et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Article Medicine, Research & Experimental

Iron chelation as novel treatment for lung inflammation in cystic fibrosis

Maral Aali et al.

MEDICAL HYPOTHESES (2017)

Review Nutrition & Dietetics

Benefits of Lactoferrin, Osteopontin and Milk Fat Globule Membranes for Infants

Hans Demmelmair et al.

NUTRIENTS (2017)

Review Immunology

Lactoferrin in a Context of Inflammation-Induced Pathology

Marian L. Kruzel et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Endocrinology & Metabolism

Iron Nutriture of the Fetus, Neonate, Infant, and Child

Carla Cerami

ANNALS OF NUTRITION AND METABOLISM (2017)

Article Nutrition & Dietetics

Iron homeostasis during pregnancy

Allison L. Fisher et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2017)

Article Biochemistry & Molecular Biology

Anticancer activities of bovine and human lactoferricin-derived peptides

Mauricio Arias et al.

BIOCHEMISTRY AND CELL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Iron uptake and transport across physiological barriers

Kari A. Duck et al.

BIOMETALS (2016)

Article Medicine, General & Internal

Breastfeeding and Complementary Feeding Recommendations on Infant Nutrition

Christine Prell et al.

DEUTSCHES ARZTEBLATT INTERNATIONAL (2016)

Article Endocrinology & Metabolism

Supplementation during pregnancy: beliefs and science

Nils Milman et al.

GYNECOLOGICAL ENDOCRINOLOGY (2016)

Article Pediatrics

Overview of Lactoferrin as a Natural Immune Modulator

Dominique Legrand

JOURNAL OF PEDIATRICS (2016)

Article Marine & Freshwater Biology

Ligand Field Theory and the Origin of Life as an Emergent Feature of the Periodic Table of Elements

Harold J. Morowitz et al.

BIOLOGICAL BULLETIN (2016)

Article Multidisciplinary Sciences

Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney

Bo Jiang et al.

SCIENTIFIC REPORTS (2016)

Article Physiology

Iron homeostasis and its disruption in mouse lung in iron deficiency and overload

Gisela Giorgi et al.

EXPERIMENTAL PHYSIOLOGY (2015)

Review Biochemistry & Molecular Biology

Thrombophilia and Pregnancy Complications

Louise E. Simcox et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Review Pharmacology & Pharmacy

The iron-regulatory hormone hepcidin: A possible therapeutic target?

Luc Rochette et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Article Endocrinology & Metabolism

A novel model for brain iron uptake: introducing the concept of regulation

Ian A. Simpson et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

Article Biochemistry & Molecular Biology

Aerosolized bovine lactoferrin reduces lung injury and fibrosis in mice exposed to hyperoxia

Hsiao-Ling Chen et al.

BIOMETALS (2014)

Review Biochemistry & Molecular Biology

Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration

Hjalte Holm Andersen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

Review Clinical Neurology

The role of iron in brain ageing and neurodegenerative disorders

Roberta Ward et al.

LANCET NEUROLOGY (2014)

Article Genetics & Heredity

Identification of erythroferrone as an erythroid regulator of iron metabolism

Leon Kautz et al.

NATURE GENETICS (2014)

Article Multidisciplinary Sciences

Increased Iron Sequestration in Alveolar Macrophages in Chronic Obtructive Pulmonary Disease

Quentin Philippot et al.

PLOS ONE (2014)

Article Biochemistry & Molecular Biology

Ferroportin and Exocytoplasmic Ferroxidase Activity Are Required for Brain Microvascular Endothelial Cell Iron Efflux

Ryan C. McCarthy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Respiratory System

Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients

Andrew J. Ghio et al.

JOURNAL OF CYSTIC FIBROSIS (2013)

Article Biochemistry & Molecular Biology

Recognition of specific and nonspecific DNA by human lactoferrin

Tat'yana A. Guschina et al.

JOURNAL OF MOLECULAR RECOGNITION (2013)

Article Biochemistry & Molecular Biology

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

Pamela Urrutia et al.

JOURNAL OF NEUROCHEMISTRY (2013)

Review Nutrition & Dietetics

Pregnancy and iron homeostasis: an update

Chang Cao et al.

NUTRITION REVIEWS (2013)

Article Multidisciplinary Sciences

The Amyloid Precursor Protein (APP) Does Not Have a Ferroxidase Site in Its E2 Domain

Kourosh Honarmand Ebrahimi et al.

PLOS ONE (2013)

Review Medicine, General & Internal

Hepcidin-Minireview

Subha M. Palaneeswari et al.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2013)

Article Biochemistry & Molecular Biology

Mechanisms of Mammalian Iron Homeostasis

Kostas Pantopoulos et al.

BIOCHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Protection of ceruloplasmin by lactoferrin against hydroxyl radicals is pH dependent

Alexey V. Sokolov et al.

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE (2012)

Editorial Material Biochemistry & Molecular Biology

Lactoferrin, a bird's eye view INTRODUCTION

Hans J. Vogel

BIOCHEMISTRY AND CELL BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Molecular evolution of the transferrin family and associated receptors

Lisa A. Lambert

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

Article Biochemistry & Molecular Biology

Human apo-lactoferrin as a physiological mimetic of hypoxia stabilizes hypoxia-inducible factor-1 alpha

Elena T. Zakharova et al.

BIOMETALS (2012)

Article Immunology

Lactoferrin protects against lipopolysaccharide-induced acute lung injury in mice

Xi-jing Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Peng Lei et al.

NATURE MEDICINE (2012)

Article Public, Environmental & Occupational Health

Body iron delocalization: the serious drawback in iron disorders in both developing and developed countries

R. Paesano et al.

PATHOGENS AND GLOBAL HEALTH (2012)

Article Biochemistry & Molecular Biology

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

Nobuhiko Harada et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2011)

Article Medicine, Research & Experimental

Glycosylphosphatidylinositol-linked ceruloplasmin is expressed in multiple rodent organs and is lower following dietary copper deficiency

Elise J. Mostad et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2011)

Article Gastroenterology & Hepatology

Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic β-cells

David M. Hudson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Review Nutrition & Dietetics

Iron Homeostasis and the Inflammatory Response

Marianne Wessling-Resnick

ANNUAL REVIEW OF NUTRITION, VOL 30 (2010)

Article Medicine, Research & Experimental

Effect of Lactoferrin on Consequences of Acute Experimental Hemorrhagic Anemia in Rats

M. O. Pulina et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2010)

Article Immunology

Differential regulation of iron homeostasis during human macrophage polarized activation

Stefania Recalcati et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2010)

Article Hematology

Polarization dictates iron handling by inflammatory and alternatively activated macrophages

Gianfranca Corna et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2010)

Review Genetics & Heredity

Beta-thalassemia

Renzo Galanello et al.

ORPHANET JOURNAL OF RARE DISEASES (2010)

Article Hematology

Haemostatic reference intervals in pregnancy

Pal B. Szecsi et al.

THROMBOSIS AND HAEMOSTASIS (2010)

Review Biochemistry & Molecular Biology

Disruption of iron homeostasis and lung disease

Andrew J. Ghio

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

Article Biochemistry & Molecular Biology

Effect of lactoferrin on oxidative features of ceruloplasmin

Alexej V. Sokolov et al.

BIOMETALS (2009)

Review Neurosciences

Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis

Sandro Altamura et al.

JOURNAL OF ALZHEIMERS DISEASE (2009)

Article Neurosciences

A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

Pier Giorgio Mastroberardino et al.

NEUROBIOLOGY OF DISEASE (2009)

Article Geochemistry & Geophysics

Atmospheric Iron Deposition: Global Distribution, Variability, and Human Perturbations

Natalie M. Mahowald et al.

Annual Review of Marine Science (2008)

Article Biochemistry & Molecular Biology

The N1 domain of human lactoferrin is required for internalization by Caco-2 cells and targeting to the nucleus

Yasushi A. Suzuki et al.

BIOCHEMISTRY (2008)

Article Pharmacology & Pharmacy

Recombinant human intelectin binds bovine lactoferrin and its peptides

Kouichirou Shin et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2008)

Article Multidisciplinary Sciences

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

Julio Salazar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Immunology

Uptake of ingested bovine lactoferrin and its accumulation in adult mouse tissues

Romy Fischer et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2007)

Article Gastroenterology & Hepatology

A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants

James C. King et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2007)

Article Cell Biology

Release of iron from ferritin requires lysosomal activity

Theodros Z. Kidane et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

Interaction of human lactoferrin with cell adhesion molecules through RGD motif elucidated by lactoferrin-binding epitopes

Kotaro Sakamoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Oral administration of lactoferrin increases hemoglobin and total serum iron in pregnant women

Rosalba Paesano et al.

BIOCHEMISTRY AND CELL BIOLOGY (2006)

Article Pharmacology & Pharmacy

The influence of high iron diet on rat lung manganese absorption

K Thompson et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2006)

Review Biochemistry & Molecular Biology

Evolution of the transferrin family: Conservation of residues associated with iron and anion binding

LA Lambert et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Identification of an intestinal heme transporter

M Shayeghi et al.

Article Clinical Neurology

Blood-brain barrier dysfunction in Parkinsonian midbrain in vivo

R Kortekaas et al.

ANNALS OF NEUROLOGY (2005)

Review Biochemistry & Molecular Biology

Structure/function overview of proteins involved in iron storage and transport

PJ Sargent et al.

CURRENT MEDICINAL CHEMISTRY (2005)

Review Biochemistry & Molecular Biology

Evolution of duplications in the transferrin family of proteins

LA Lambert et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Cellular internalization of lactoferrin in intestinal epithelial cells

K Ashida et al.

BIOMETALS (2004)

Article Biochemistry & Molecular Biology

Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease

BA Faucheux et al.

JOURNAL OF NEUROCHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system

SY Jeong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Hematology

The orchestration of body iron intake: how and where do enterocytes receive their cues?

DM Frazer et al.

BLOOD CELLS MOLECULES AND DISEASES (2003)

Article Physiology

Iron increases expression of iron-export protein MTP1 in lung cells

FM Yang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2002)

Article Clinical Neurology

Association study between iron-related genes polymorphisms and Parkinson's disease

C Borie et al.

JOURNAL OF NEUROLOGY (2002)

Article Anatomy & Morphology

Astrocyte-endothelial interactions and blood-brain barrier permeability

NJ Abbott

JOURNAL OF ANATOMY (2002)

Article Biochemistry & Molecular Biology

Molecular cloning and functional expression of a human intestinal lactoferrin receptor

YA Suzuki et al.

BIOCHEMISTRY (2001)

Article Nutrition & Dietetics

Gastric digestion of bovine lactoferrin in vivo in adults

FJ Troost et al.

JOURNAL OF NUTRITION (2001)

Review Medicine, General & Internal

Medical progress - The acute respiratory distress syndrome.

LB Ware et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)

Article Biochemistry & Molecular Biology

Interaction of lactoferrin with ceruloplasmin

ET Zakharova et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)