Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 153, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.113279
Keywords
Cardiomyopathy; Ferroptosis; Cell death; Heart failure; GPX4; Lipid ROS; Lipid peroxidation
Ask authors/readers for more resources
Heart disease is the leading cause of death globally. Cardiomyopathy, a type of heart disease, is characterized by heart muscle damage that leads to structural and functional changes in the heart, resulting in heart failure and sudden cardiac death. The loss of cardiomyocytes is a key factor in the development of cardiomyopathy, and recent studies have highlighted the role of ferroptosis, a regulated form of cell death involving iron accumulation and lipid peroxidation, in this disease.
Heart disease is the leading cause of death worldwide. Cardiomyopathy is a disease characterized by the heart muscle damage, resulting heart in a structurally and functionally change, as well as heart failure and sudden cardiac death. The key pathogenic factor of cardiomyopathy is the loss of cardiomyocytes, but the related molecular mechanisms remain unclear. Ferroptosis is a newly discovered regulated form of cell death, characterized by iron accumulation and lipid peroxidation during cell death. Recent studies have shown that ferroptosis plays
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available