Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 155, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.113712
Keywords
Atherosclerosis; Natural bioactive compounds; Herbal medicines; Autophagy
Funding
- National Natural Science Foundation of China [82004062]
- Research Program of Tianjin Munic- ipal Education Commission [2017KJ129, 2021-QNRC2-B12]
Ask authors/readers for more resources
Atherosclerosis, characterized by the formation of plaques in arterial walls, is a common cardiovascular disease. Natural compounds from herbs and natural products have been found to induce autophagy and inhibit the occurrence and development of atherosclerosis, offering potential therapeutic strategies.
Atherosclerosis (AS) is the most common causes of cardiovascular disease characterized by the formation of atherosclerotic plaques in the arterial wall, and it has become a dominant public health problem that seriously threaten people worldwide. Autophagy is a cellular self-catabolism process, which is critical to protect cellular homeostasis against harmful conditions. Emerging evidence suggest that dysregulated autophagy is involved in the development of AS. Therefore, pharmacological interventions have been developed to inhibit the AS via autophagy induction. Among various AS treating methods, herbal medicines and natural products have been applied as effective complementary and alternative medicines to ameliorate AS and its associated cardiovascular disease. Recently, mounting evidence revealed that natural bioactive compounds from herbs and natural prod-ucts could induce autophagy to suppress the occurrence and development of AS, by promoting cholesterol efflux, reducing plaque inflammation, and inhibiting apoptosis or senescence. In the present review, we highlight recent findings regarding possible effects and molecular mechanism of natural compounds in autophagy-targeted mitigation of atherosclerosis, aiming to provide new potential therapeutic strategies for the atherosclerosis treatment preclinically and clinically.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available