Biomaterial-embedded extracellular vesicles improve recovery of the dysfunctional myocardium

Article Cardiac & Cardiovascular Systems

Minimally invasive delivery of a hydrogel-based exosome patch to prevent heart failure

George Cheng et al.

Summary: Coronary heart disease is the leading cause of death in the United States. Injecting a hydrogel containing exosomes has shown potential in reducing heart chamber size and preserving wall thickness.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

Mesenchymal Stem Cell (MSCs) Therapy for Ischemic Heart Disease: A Promising Frontier

Merlin Sobia Poomani et al.

Summary: Cell-based therapeutics, particularly using mesenchymal stem cells, shows promising potential for regenerating the heart and treating ischemic heart disease, with successful pre-clinical and clinical trial results.

GLOBAL HEART (2022)

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Review Cell & Tissue Engineering

Extracellular Vesicles as a Cell-free Therapy for Cardiac Repair: a Systematic Review and Meta-analysis of Randomized Controlled Preclinical Trials in Animal Myocardial Infarction Models

Kashif Khan et al.

Summary: Stem cell-derived extracellular vesicles (EVs) show promise as a novel therapy for cardiac repair after myocardial infarction (MI) in animal models. This systematic review and meta-analysis demonstrate significant improvements in ejection fraction (EF) and fractional shortening (FS) in small animals treated with EVs, particularly those derived from mesenchymal stem cells. However, further investigations are needed before clinical trials can be conducted.

STEM CELL REVIEWS AND REPORTS (2022)

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Article Nanoscience & Nanotechnology

Restoring Cardiac Functions after Myocardial Infarction-Ischemia/Reperfusion via an Exosome Anchoring Conductive Hydrogel

Yang Zou et al.

Summary: A novel injectable conductive hydrogel was designed for treating myocardial injuries after myocardial infarction. The hydrogel, containing exosomes derived from stem cells cross-linked via an epoxy/thiol click reaction, effectively improved cardiac functions, promoted cell-to-cell interactions, and angiogenesis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Biochemistry & Molecular Biology

Extracellular Vesicles and Biomaterial Design: New Therapies for Cardiac Repair

Chloe Pezzana et al.

Summary: EVs play a crucial role in the paracrine effects of stem cells, but face challenges in delivery such as fast wash-out and whole-body distribution limits. Researchers are exploring different administration routes to enhance the residence time and targeting of EVs in the target tissue.

TRENDS IN MOLECULAR MEDICINE (2021)

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Article Chemistry, Multidisciplinary

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

Jialu Yao et al.

Summary: Myocardial infarction is the most common cause of death worldwide, with heart failure becoming a major determinant of adverse prognosis in survivors. Exosome spray (EXOS) based on MSC exosomes and biomaterials shows promise in improving heart function, reducing fibrosis, and promoting angiomyogenesis for heart repair, making it a feasible and safe strategy for future therapeutic delivery.

ACS NANO (2021)

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Article Medicine, General & Internal