Journal
BIOMARKERS IN MEDICINE
Volume 16, Issue 14, Pages 1055-1066Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2022-0287
Keywords
CA125; epithelial ovarian cancer; FIGO; HE4; recurrence; ROMA index
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Funding
- Ningxia Key Research and Development Program [2019BFG02002]
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This study assessed the predictive and diagnostic value of the ROMA index for EOC recurrence. The results showed that the ROMA index was strongly associated with clinical characteristics and had a significant association with recurrence-free survival above the cutoff value. The ROMA index had a higher sensitivity than CA125 and HE4 for recurrence diagnosis.
Aim: This study aimed to assess the predictive and diagnostic value of the risk of ovarian malignancy algorithm (ROMA) index for epithelial ovarian cancer (EOC) recurrence. Materials & methods: The clinical features and follow-up data of 159 EOC cases were studied. The ROMA index was calculated by serum CA125 and HE4 levels with menopausal status. Recurrence-free survival was evaluated for an end point. Results: The ROMA was strongly associated with clinical characteristics. The ROMA index above the cutoff value (34.71%) was significantly associated with recurrence-free survival. The ROMA index had a significantly higher sensitivity (90.59%) than CA125 (84.71%) and HE4 (80.80%) for recurrence diagnosis, and its optimal cutoff value was 17.07%. Conclusion: The primary ROMA index is a predictive factor in EOC recurrence and has better performance in the diagnosis of EOC recurrence.
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