Raised total methylated arginine load in patients with gout

Aim: The aim of this study was to measure serum levels of methylarginine derivatives and related metabolites in patients with gout. Materials & methods: This study enrolled 100 patients with gout and 80 patients in the control group. Serum asymmetric dimethylarginine, symmetric dimethylarginine, L-N-monomethylarginine, arginine, homoarginine, citrulline and ornithine levels were measured with tandem mass spectrometry. Results: Serum ornithine, citrulline and total methylated arginine load levels were statistically significantly higher in patients with gout compared with the control group, while serum arginine and homoarginine levels and global arginine bioavailability ratio were statistically significantly lower. Conclusion: There may be an association between gout, methylarginine levels and hyperuricemia and increased risk of cardiovascular disease.

Automated summary

This study found that serum levels of methylarginine derivatives and related metabolites were higher in patients with gout compared to the control group, while serum levels of arginine and homoarginine were lower. There may be an association between gout, methylarginine levels, hyperuricemia, and increased risk of cardiovascular disease.