Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1877, Issue 5, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbcan.2022.188795
Keywords
Skin; Basal cell carcinoma; Sonic hedgehog; Hedgehog; Wnt; Notch; Skin homeostasis; Hair follicle; Hair follicle homeostasis; Skin differentiation; Hair follicle differentiation; Edar; Eda; Dermal condensate; Dermal papilla; Epidermal placode; Hair placode
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This study investigates the role of the Notch signaling pathway in hair follicle and epidermal homeostasis. Loss of Notch signaling leads to the development of BCC and drug resistance in BCC cells.
Hedgehog signaling (Hh) plays a critical role in embryogenesis. On the other hand, its overactivity may cause basal cell carcinoma (BCC), the most common human cancer. Further, epidermal and hair follicle homeostases may have a key role in the development of BCC. This article describes the importance of different signaling pathways in the different stages of the two processes. The description of the homeostases brought up the importance of the Notch signaling along with the sonic hedgehog (Shh) and the Wnt pathways. Loss of the Notch signaling adversely affects the late stages of hair follicle formation and allows the bulge cells in the hair follicles to take the fate of the keratinocytes in the interfollicular epidermis. Further, the loss of Notch activity upregulates the Shh and Wnt activities, adversely affecting the homeostases. Notably, the Notch signaling is suppressed in BCC, and the peripheral BCC cells, which have low Notch activity, show drug resistance in comparison to the interior suprabasal BCC cells, which have high Notch activity.
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