Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1877, Issue 6, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbcan.2022.188814
Keywords
Unfolded protein response (UPR); Clear cell renal cell carcinoma (ccRCC); Tumourigenesis
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Funding
- Precision Oncology Ireland - Science Foundation Ireland (SFI) Strategic Partnership Programme [18/SPP/3522]
- European Union [945425]
- IRC-Government of Ireland Postgraduate Scholarship [GOIPG/2022/1708]
- Marie Curie Actions (MSCA) [945425] Funding Source: Marie Curie Actions (MSCA)
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Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, with low long-term survival in patients diagnosed with advanced disease. The unfolded protein response (UPR) has been found to play a role in ccRCC and may offer potential therapeutic targets in the future.
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer. Despite therapeutic advances, long term survival in patients diagnosed with advanced disease is low. Efforts to understand the mechanisms promoting disease progression will likely produce novel therapeutic targets. The unfolded protein response (UPR) is activated when unfolded protein accumulates in the endoplasmic reticulum (ER) upon cellular stress. Constitutive UPR activation is a characteristic of many malignancies. We discuss the accumulating evidence that describes a role for the UPR in ccRCC. Studies focused on UPR signalling may provide compelling avenues for therapeutic intervention in the future.
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