4.7 Article

Reduced hydration regulates pro-inflammatory cytokines via CD14 in barrier function-impaired skin

Related references

Note: Only part of the references are listed.
Article Dermatology

Aged and young mice differentially respond to tape-stripping in epidermal gene expression

Si Wen et al.

Summary: Disruption of the epidermal permeability barrier leads to upregulation of inflammation-associated genes and downregulation of epidermal structure- and development-related genes in aged mice, while young mice mainly exhibit upregulation of inflammation-related genes and downregulation of epidermal structure-related genes in response to barrier disruption.

EXPERIMENTAL DERMATOLOGY (2022)

Article Allergy

Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis

Helen He et al.

Summary: This study utilized RNA-seq analysis of tape strips from lesional and nonlesional skin of patients with moderate-to-severe AD and psoriasis, revealing distinct immune and barrier signatures in the two diseases. The findings suggest the potential utility of tape strips as a minimally invasive alternative to biopsies for detecting disease biomarkers. Differences in gene expression profiles between AD and psoriasis highlight the unique pathophysiological mechanisms of these two skin disorders.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Medicine, General & Internal

Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity

Trinidad Montero-Vilchez et al.

Summary: This study compared skin barrier function between healthy skin, psoriatic skin, and atopic dermatitis skin, finding that TEWL was higher at psoriatic and AD lesions, while SCH was lower. Specific TEWL and temperature values may help clinicians determine disease severity and treatment needs.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Medicine, General & Internal

Phase 1b dose-escalation, safety, and pharmacokinetic study of IC14, a monoclonal antibody against CD14, for the treatment of amyotrophic lateral sclerosis

Robert D. Henderson et al.

Summary: The study aimed to demonstrate the safety and tolerability of monoclonal antibody IC14 in ALS patients, showing rapid and sustained target saturation of monocyte CD14 receptors, but no significant changes in disease status and biomarkers following a single cycle of treatment.

MEDICINE (2021)

Article Rheumatology

Lipopolysaccharide Binding Protein and CD14, Cofactors of Toll-like Receptors, Are Essential for Low-Grade Inflammation-Induced Exacerbation of Cartilage Damage in Mouse Models of Posttraumatic Osteoarthritis

Yoonkyung Won et al.

Summary: Low-grade inflammation associated with Toll-like receptor (TLR) signaling components such as TLR-2, TLR-4, lipopolysaccharide binding protein (LBP), and CD14 exacerbates posttraumatic OA cartilage destruction. High-fat diet or endotoxemia-induced low-grade inflammation enhances cartilage destruction in mice, and this effect is significantly reduced in LBP-/- and CD14(-/-) mice. LBP and CD14 are necessary for the expression of matrix-degrading enzymes in mouse chondrocytes treated with proinflammatory cytokines.

ARTHRITIS & RHEUMATOLOGY (2021)

Article Medicine, Research & Experimental

Knockdown of sodium channel Nax reduces dermatitis symptoms in rabbit skin

Jingling Zhao et al.

LABORATORY INVESTIGATION (2020)

Article Medicine, General & Internal

Pharmacological validation of targets regulating CD14 during macrophage differentiation

Gisela Jimenez-Duran et al.

EBIOMEDICINE (2020)

Article Biochemistry & Molecular Biology

Biglycan is a new high-affinity ligand for CD14 in macrophages

Heiko Roedig et al.

MATRIX BIOLOGY (2019)

Article Dermatology

Imiquimod-induced skin inflammation is relieved by knockdown of sodium channel Nax

Jingling Zhao et al.

EXPERIMENTAL DERMATOLOGY (2019)

Review Biochemistry & Molecular Biology

CD14: Biology and role in the pathogenesis of disease

Zhenghao Wu et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2019)

Review Immunology

The Role of Toll-Like Receptors in Skin Host Defense, Psoriasis, and Atopic Dermatitis

Lixiang Sun et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2019)

Article Dermatology

Increased epidermal thickness and abnormal epidermal differentiation in keloid scars

G. C. Limandjaja et al.

BRITISH JOURNAL OF DERMATOLOGY (2017)

Article Dermatology

S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis

Jingling Zhao et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

Article Critical Care Medicine

Transepidermal water loss measured with the Tewameter TM300 in burn scars

Kim L. M. Gardien et al.

BURNS (2016)

Article Dermatology

Measurement of transepidermal water loss in localized scleroderma

Veronika Durcanska et al.

DERMATOLOGIC THERAPY (2016)

Review Dermatology

Psoriasis as a barrier disease

Shigetoshi Sano

DERMATOLOGICA SINICA (2015)

Article Cell Biology

Sodium channel Nax is a regulator in epithelial sodium homeostasis

Wei Xu et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Article Dermatology

The Expression of Proinflammatory Genes in Epidermal Keratinocytes Is Regulated by Hydration Status

Wei Xu et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Article Biochemistry & Molecular Biology

Signaling of High Mobility Group Box 1 (HMGB1) through Toll-like Receptor 4 in Macrophages Requires CD14

Sodam Kim et al.

MOLECULAR MEDICINE (2013)

Article Cell Biology

Targeting the TLR Co-Receptor CD14 with TLR2-Derived Peptides Modulates Immune Responses to Pathogens

Anne-Catherine Raby et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Review Immunology

Role of CD14 in host protection against infections and in metabolism regulation

Ivan Zanoni et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2013)

Article Biochemistry & Molecular Biology

S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin

Young Lee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Dermatology

Abnormal epidermal barrier in the pathogenesis of psoriasis

Ronni Wolf et al.

CLINICS IN DERMATOLOGY (2012)

Article Multidisciplinary Sciences

Effects of Hepatocyte CD14 Upregulation during Cholestasis on Endotoxin Sensitivity

Ming-Huei Chou et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

Ivan Zanoni et al.

Article Dermatology

Epithelial Regulation of Mesenchymal Tissue Behavior

Corrie L. Gallant-Behm et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

Article Dentistry, Oral Surgery & Medicine

Soluble CD14 induces cytokine release by human oral epithelial cells

K. Feghali et al.

JOURNAL OF PERIODONTAL RESEARCH (2011)

Article Immunology

CD14 is a coreceptor of Toll-like receptors 7 and 9

Christoph L. Baumann et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Article Dermatology

Epithelial Cells Promote Fibroblast Activation via IL-1α in Systemic Sclerosis

Nima Aden et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)

Article Immunology

A Lecinoxoid, an oxidized phospholipid small molecule, constrains CNS autoimmune disease

Itzhak Mendel et al.

JOURNAL OF NEUROIMMUNOLOGY (2010)

Article Medicine, Research & Experimental

Endotoxin and CD14 in the progression of biliary atresia

Ming-Huei Chou et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2010)

Article Urology & Nephrology

Renal CD14 expression correlates with the progression of cystic kidney disease

Juling Zhou et al.

KIDNEY INTERNATIONAL (2010)

Article Biochemistry & Molecular Biology

Evidence of a Specific Interaction between New Synthetic Antisepsis Agents and CD14

Matteo Piazza et al.

BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes

Takamasa Nukui et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2008)

Article Medicine, Research & Experimental

Attenuation of the cardiovascular and metabolic complications of obesity in CD14 knockout mice

Roberto Roncon-Albuquerque et al.

LIFE SCIENCES (2008)

Review Medicine, Research & Experimental

Epidermal barrier formation and recovery in skin disorders

JA Segre

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Physiology

Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney

TM El-Achkar et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)

Review Cell Biology

Time to abandon dogma: CD14 is expressed by non-myeloid lineage cells

HPA Jersmann

IMMUNOLOGY AND CELL BIOLOGY (2005)

Article Immunology

CD14 is an acute-phase protein

S Bas et al.

JOURNAL OF IMMUNOLOGY (2004)

Article Dermatology

Human keratinocytes express functional CD14 and toll-like receptor 4

PI Song et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2002)

Article Gastroenterology & Hepatology

Lipopolysaccharide induced synthesis CD14 protein and its gene expression in during hepatocytes during endotoxemia

SW Li et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2002)

Article Immunology

Reduced early alcohol-induced liver injury in CD14-deficient mice

M Yin et al.

JOURNAL OF IMMUNOLOGY (2001)