Journal
BIOCHEMICAL PHARMACOLOGY
Volume 205, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2022.115259
Keywords
Adventitia; Myofibroblast; Progenitor cells; Smooth muscle; Reprogramming
Categories
Funding
- National Heart, Lung, and Blood Institute of the National Institutes of Health [R01HL123650, R01HL121877, R01HL133723]
- Loie Power Robinson Stem Cell and Regenerative Medicine Fund
- Seattle Children's Research Institute, Seattle, WA
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The adventitia is a complex and dynamic tissue that receives input signals from various sources to regulate the structural and mechanical properties of blood vessels. It plays a crucial role in vascular development, homeostasis, and repair.
The adventitia receives input signals from the vessel wall, the immune system, perivascular nerves and from surrounding tissues to generate effector responses that regulate structural and mechanical properties of blood vessels. It is a complex and dynamic tissue that orchestrates multiple functions for vascular development, homeostasis, repair, and disease. The purpose of this review is to highlight recent advances in our understanding of the origins, phenotypes, and functions of adventitial and perivascular cells with particular emphasis on hypertensive vascular remodeling.
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