Journal
BIOCHEMICAL PHARMACOLOGY
Volume 203, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2022.115177
Keywords
Atopic dermatitis; Mouse models; Hapten; Allergen; Bacterial infection; Engineered mouse
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Funding
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [2021R1A2C1005865]
- National Research Foundation of Korea [2021R1A2C1005865] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This article summarizes mouse models of atopic dermatitis (AD) and describes their characteristics from a researcher's perspective.
Atopic dermatitis (AD) is a dermatological disease accompanied by dry and cracked skin with severe pruritus. Although various therapeutic strategies have been introduced to alleviate AD, it remains challenging to cure the disorder. To achieve such a goal, understanding the pathophysiological mechanisms of AD is a prerequisite, requiring mouse models that properly reflect the AD phenotypes. Currently, numerous AD mouse models have been established, but each model has its own advantages and weaknesses. In this review, we categorized and summarized mouse models of AD and described their characteristics from a researcher's perspective.
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