4.5 Article

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Related references

Note: Only part of the references are listed.
Article Hematology

The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma

Baptiste Eluard et al.

Summary: RelB activation is frequently observed in DLBCL and defines a new subset of patients with distinct gene expression profile and mutational pattern. RelB positivity is associated with poor prognosis after immunochemotherapy, and it confers resistance to doxorubicin-induced apoptosis in DLBCL cells.

BLOOD (2022)

Article Biochemistry & Molecular Biology

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant E?-Myc lymphoma cells

Jill E. Hunter et al.

Summary: In this study, we discovered the up-regulation of multiple bypass pathways in lymphomas with mutant NF-kappa B subunits, and demonstrated that drugs targeting these pathways could potentially be used to aid the successful clinical application of CHK1 inhibitors.

BIOCHEMICAL JOURNAL (2022)

Article Biochemistry & Molecular Biology

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Jill E. Hunter et al.

Summary: DNA replication stress is a common feature of cancer cells, and ATR/CHK1 signaling pathway is an attractive target for anti-cancer therapies. This study reveals the critical role of RelA NF-xB subunit in MYC induced DNA replication stress, suggesting its potential as a therapeutic target.

BIOCHEMICAL JOURNAL (2022)

Article Oncology

Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy

Maelle Cartel et al.

Summary: The research demonstrates that inhibition of deubiquitinylase USP7 reduces cell proliferation, blocks DNA replication, and increases cell death in AML. High expression of USP7 is associated with resistance to therapy in AML patients, indicating USP7 as both a marker of resistance and a potential therapeutic target for overcoming treatment resistance.

LEUKEMIA (2021)

Review Oncology

Deubiquitinases in hematological malignancies

Hu Lei et al.

Summary: Recent studies have identified certain DUBs as promising therapeutic targets in hematological malignancies, with the development of potent inhibitors showing promising inhibitory efficacy. Different DUBs play distinct roles in various types of blood cancers, emphasizing the importance of exploring their biological functions for potential therapeutic targets.

BIOMARKER RESEARCH (2021)

Review Biochemistry & Molecular Biology

Claspin - checkpoint adaptor and DNA replication factor

Veronique A. J. Smits et al.

FEBS JOURNAL (2019)

Article Biochemical Research Methods

DNA Binding and Phosphorylation Regulate the Core Structure of the NF-B p50 Transcription Factor

Matthias Vonderach et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2019)

Review Pharmacology & Pharmacy

USP7: Novel Drug Target in Cancer Therapy

Zhiru Wang et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Multidisciplinary Sciences

USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability

Maura Sonego et al.

SCIENCE ADVANCES (2019)

Article Biochemistry & Molecular Biology

USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis

Aihui Ma et al.

ONCOGENE (2019)

Article Biochemistry & Molecular Biology

USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors

Kah Suan Lim et al.

MOLECULAR CELL (2018)

Article Immunology

USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses

Zhongxia Yu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Biochemical Research Methods

Evaluation of Parameters for Confident Phosphorylation Site Localization Using an Orbitrap Fusion Tribrid Mass Spectrometer

Samantha Ferries et al.

JOURNAL OF PROTEOME RESEARCH (2017)

Article Biochemical Research Methods

Salmon provides fast and bias-aware quantification of transcript expression

Rob Patro et al.

NATURE METHODS (2017)

Article Biochemistry & Molecular Biology

The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma

J. E. Hunter et al.

ONCOGENE (2016)

Review Biochemistry & Molecular Biology

Myc induced replicative stress response: How to cope with it and exploit it

Sara Rohban et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2015)

Article Oncology

HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP

Seemana Bhattacharya et al.

CELLULAR ONCOLOGY (2015)

Article Biochemistry & Molecular Biology

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses

Qin Liang et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Review Biochemistry & Molecular Biology

USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy

Iraia Garcia-Santisteban et al.

MOLECULAR CANCER (2013)

Article Oncology

Small-Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells

Helena Mistry et al.

MOLECULAR CANCER THERAPEUTICS (2013)

Article Biochemistry & Molecular Biology

The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

Juan Antonio Vizcaino et al.

NUCLEIC ACIDS RESEARCH (2013)

Review Biochemistry & Molecular Biology

Ubiquitin and Proteasomes in Transcription

Fuqiang Geng et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Review Biochemistry & Molecular Biology

Mechanisms of replication fork protection: a safeguard for genome stability

Alessia Errico et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2012)

Review Cell Biology

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

Hyungjin Kim et al.

GENES & DEVELOPMENT (2012)

Article Multidisciplinary Sciences

The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition

Ruth Thompson et al.

PLOS ONE (2012)

Review Oncology

The diverse and complex roles of NF-κB subunits in cancer

Neil D. Perkins

NATURE REVIEWS CANCER (2012)

Article Biochemistry & Molecular Biology

USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation

Jean-Hugues Guervilly et al.

HUMAN MOLECULAR GENETICS (2011)

Article Biochemistry & Molecular Biology

p50 (NF-κB1) Is an Effector Protein in the Cytotoxic Response to DNA Methylation Damage

Adam M. Schmitt et al.

MOLECULAR CELL (2011)

Article Biochemical Research Methods

MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics

Lily Ting et al.

NATURE METHODS (2011)

Article Biochemistry & Molecular Biology

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

Matilde Murga et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Review Pharmacology & Pharmacy

Anticancer therapy with checkpoint inhibitors: what, where and when?

Michelle D. Garrett et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2011)

Article Biotechnology & Applied Microbiology

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

Melanie Blasius et al.

GENOME BIOLOGY (2011)

Article Biochemistry & Molecular Biology

IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function

Niall Steven Kenneth et al.

EMBO JOURNAL (2010)

Article Cell Biology

Oncogenic Activation of NF-kappa B

Louis M. Staudt

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Review Oncology

The biology of Hodgkin's lymphoma

Ralf Kueppers

NATURE REVIEWS CANCER (2009)

Article Biochemistry & Molecular Biology

Regulation of the ReIA (p65) transactivation domain

John M. O'Shea et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2008)

Article Biochemistry & Molecular Biology

Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair

Rachel W. Anantha et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

DNA replication stress, genome instability and aging

William C. Burhans et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Biochemistry & Molecular Biology

RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint

Erin Olson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Cell Biology

Regulation of DNA repair by ubiquitylation

TT Huang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Regulation of NF-κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

S Rocha et al.

EMBO JOURNAL (2005)

Review Biochemistry & Molecular Biology

Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation

P Viatour et al.

TRENDS IN BIOCHEMICAL SCIENCES (2005)

Article Biochemistry & Molecular Biology

p53- and Mdm2-independent repression of NF-κB transactivation by the ARF tumor suppressor

S Rocha et al.

MOLECULAR CELL (2003)