Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 630, Issue -, Pages 175-182Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2022.09.050
Keywords
Drebrin; Lung adenocarcinoma; Migration; Integrin beta 1 endocytosis
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Funding
- National Natural Science Foundation of China [82030087, 81530084, 81974465, 81900199]
- Hunan province natural science funds for Excellent Yong scholars [2019JJ30043]
- recruitment program for Huxiang Talents [2019RS1009]
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This study demonstrated the critical role of Drebrin in LUAD and the associated mechanism. Drebrin can promote migration and invasion of LUAD cells, and its high expression predicts poor prognosis.
Lung adenocarcinoma (LUAD) is the most common type of lung cancers, which remains the leading cause of cancer-related death worldwide. Drebrin can promote cell migration and invasion with poor prognosis, but its roes in LUAD tumor progression remains unknown. We showed that the expression of Drebrin was upregulated in clinical LUAD samples. A Kaplan-Meier survival analysis showed that a high expression of Drebrin predicated poor prognosis in LUAD. In vitro, Drebrin promoted anchorage-independent growth and migration of LUAD cells. Drebrin interacted with dynamin through CT domain, and served as an adaptor to promote LUAD cell migration through inducing integrin beta 1 endocytosis. Thus, this study demonstrated the critical role of Drebrin in LUAD and associated mechanism. (C) 2022 Elsevier Inc. All rights reserved.
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