HS1BP3, transcriptionally regulated by ESR1, promotes hepatocellular carcinoma progression

Purpose: To explore the role of HS1-binding protein 3 (HS1BP3) in hepatocellular carcinoma (HCC) and the potential mechanism. Methods: The effect of HS1BP3 in the prognosis of HCC was analyzed. The influence of HS1BP3 silence on proliferation, migration, cell cycle, and apoptosis of HCC cells (Huh-7 and Sun-449) were evaluated. The upstream transcription factors of HS1BP3 were further explored. Results: The high expression of HS1BP3 in HCC was significantly associated with poor prognosis. The silencing of HS1BP3 inhibited proliferation, invasion, migration, and promoted G1 phase cell cycle arrest and apoptosis of HCC cells. Estrogen receptors 1 (ESR1) inhibited proliferation and improved the prognosis of HCC via fusion with HS1BP3 promoter. Conclusion: HS1BP3 may serve as a novel tumor-promoting factor transcriptionally regulated by ESR1. (C) 2022 Elsevier Inc. All rights reserved.

Automated summary

This study investigated the role and potential mechanism of HS1-binding protein 3 (HS1BP3) in hepatocellular carcinoma (HCC). The results showed that high expression of HS1BP3 was significantly associated with poor prognosis in HCC. Silence of HS1BP3 inhibited proliferation and migration, and promoted apoptosis in HCC cells. Moreover, estrogen receptor 1 (ESR1) suppressed HCC proliferation by fusion with HS1BP3 promoter.