4.7 Article

A manifesto on explainability for artificial intelligence in medicine

Journal

ARTIFICIAL INTELLIGENCE IN MEDICINE
Volume 133, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.artmed.2022.102423

Keywords

Artificial intelligence; Explainability; Explainable artificial intelligence; Interpretability; Interpretable artificial intelligence

Funding

  1. Austrian Science Fund (FWF) [P-32554]
  2. National Science Foundation (NSF), USA [IIS-2030459, IIS-2033384]
  3. US Air Force [FA8702-15-D-0001]
  4. Harvard Data Science Initiative, USA
  5. Amazon Research Award, USA
  6. Bayer Early Excellence in Science Award, USA
  7. AstraZeneca Research, United Kingdom
  8. Roche Alliance with Distinguished Scientists Award, USA
  9. project Periscope, USA (Pan-European Response to the ImpactS of COVID-19 and future Pandemics and Epidemics) - European Union [101016233]
  10. National Institutes of Health (USA) Clinical Translational Science Award [UL1-TR001878]
  11. National Institutes of Health (USA) [AG066833]
  12. Ministry of University and Research, MIUR, Project Italian Outstanding Departments, 2018-2022

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This paper focuses on the importance of explainable artificial intelligence (XAI) in the field of biomedicine. By bringing together researchers with different roles and perspectives, it explores XAI in depth and presents a series of requirements for achieving explainability in AI.
The rapid increase of interest in, and use of, artificial intelligence (AI) in computer applications has raised a parallel concern about its ability (or lack thereof) to provide understandable, or explainable, output to users. This concern is especially legitimate in biomedical contexts, where patient safety is of paramount importance. This position paper brings together seven researchers working in the field with different roles and perspectives, to explore in depth the concept of explainable AI, or XAI, offering a functional definition and conceptual framework or model that can be used when considering XAI. This is followed by a series of desiderata for attaining explainability in AI, each of which touches upon a key domain in biomedicine.

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