The Effect of Complete Prostate Examination of Radical Cystoprostatectomy Specimen on the Final Stage of Urothelial Carcinoma of the Urinary Bladder and the Detection of Prostate Cancer

center dot Context.-The prostate sampling methods for radical cystoprostatectomy (RCP) specimens may affect patholog-ic results. Objective.-To investigate the impact on the tumor stage and clinicopathologic features according to the prostate sampling method for RCP specimens.Design.-From 2016 to 2017, the prostate in RCP was minimally and conventionally embedded (group 1, n = 98). From 2017 to 2018, it was completely embedded (group 2, n = 102).Results.-Group 2 was more likely to have prostatic ducts or acini involvement by urothelial carcinoma in situ component (27% versus 10%, P = .002) and prostate involvement (30% versus 13%, P = .003) than group 1. Although there were cases with prostatic stromal invasion in group 2 (14% versus 7%, P = .13), this was not statistically significant. In all, 6 cases were upstaged by subepithelial prostatic stromal invasion through intraure-thral extension according to the 8th edition of the American Joint Committee on Cancer (AJCC) staging system. Tumor location and the presence of concurrent carcinoma in situ were strongly associated with prostate involvement of urothelial carcinoma. Prostatic adenocar-cinoma (PA) was incidentally identified in 47 cases (23.5%). Incidental PA and clinically significant PA were more often identified in group 2 than group 1 (38% versus 8%, P , .01 and 15% versus 6%, P = .048, respectively). Conclusions.-A complete prostate examination in RCP specimens can be suggested, since the final pathologic stage can be changed through a thorough prostate examination especially in accord with the AJCC staging manual 8th edition. In addition, the complete prostate analysis could detect more incidental and clinically significant PA.(Arch Pathol Lab Med. 2023;147:665-675; doi: 10.5858/ arpa.2022-0005-OA)

Automated summary

This study investigated the impact of different prostate sampling methods on the pathologic results of radical cystoprostatectomy specimens. The findings suggest that a complete embedding method can better detect urothelial carcinoma involvement in the prostate and provide more accurate diagnosis of prostatic adenocarcinoma.