Lateral flow test performance in children for SARS-CoV-2 using anterior nasal and buccal swabbing: sensitivity, specificity, negative and positive predictive values

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Peri-operative outcomes of surgery in children with SARS-CoV-2 infection

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Comparison of the pain experienced with anterior nasal swabs and nose and throat swabs in children

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ARCHIVES OF DISEASE IN CHILDHOOD (2022)

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Modelling upper respiratory viral load dynamics of SARS-CoV-2

Joseph D. Challenger et al.

Summary: The relationships between viral load, severity of illness, and transmissibility of the virus are crucial for understanding the pathogenesis of COVID-19 and developing effective therapeutic and preventive strategies. In this study, a within-host model was used to analyze the viral load dynamics in the upper respiratory tract (URT) based on data from 605 subjects. The study revealed wide variation in URT viral load between individuals, which was not explained by demographic or clinical variables. A mechanistic model was developed to describe viral load dynamics and host response, and it was found that neutralising antibodies were strongly correlated with immune-mediated control of viral load.

BMC MEDICINE (2022)

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Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study

D. Nepogodiev et al.

Summary: The study suggests that surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection, with patients experiencing ongoing symptoms >= 7 weeks from diagnosis potentially benefitting from further delay.

ANAESTHESIA (2021)

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Reactogenicity, safety and antibody response, after one and two doses of mRNA-1273 in seronegative and seropositive healthcare workers

Marie Tre-Hardy et al.

JOURNAL OF INFECTION (2021)

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Review Infectious Diseases

A systematic review of the sensitivity and specificity of lateral flow devices in the detection of SARS-CoV-2

Dylan A. Mistry et al.

Summary: This systematic review found that the performance of lateral flow devices is heterogeneous and dependent on the manufacturer. Some devices have high specificity but a great range of sensitivities were shown (38.32-99.19%). Test performance does not appear to be dependent on the operator.

BMC INFECTIOUS DISEASES (2021)

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Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study

Marta Garcia-Finana et al.

Summary: The study revealed that the sensitivity of LFT compared to RT-qPCR was low but with high specificity in asymptomatic adults. LFT may have better detection rates for individuals with high viral loads. However, the potential for missing cases, even at high viral loads, should be considered when using a single LFT in high-risk settings.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Medicine, General & Internal

COVID-19: Rapid antigen detection for SARS-CoV-2 by lateral flow assay: A national systematic evaluation of sensitivity and specificity for mass-testing

Tim Peto

Summary: The study found that four LFDs have desirable performance characteristics in viral antigen detection, with Innova LFD showing good sensitivity and specificity. The potential issues of kit failure rates and training impact were noted. LFDs can be used for mass population testing to identify infectious individuals.

ECLINICALMEDICINE (2021)

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STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies

Patrick M. Bossuyt et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

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Article Medicine, General & Internal

STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies

Patrick M. Bossuyt et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

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Lateral flow test performance in children for SARS-CoV-2 using anterior nasal and buccal swabbing: sensitivity, specificity, negative and positive predictive values

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