Conversion of proteins into DNA mimetics by lipid peroxidation

Conversion of primary amino groups to pyrrole derivatives occurs by modifying lysine residues of proteins with lipid peroxidation products. Pyrrolated proteins exhibit electronegativity and electronic properties and are recognized by DNA-binding molecules, such as anti-DNA autoantibodies and DNA intercalators. This review summarizes the state of knowledge about the chemistry of this unique conversion reaction of proteins into DNA mimetics by lipid peroxidation.

Automated summary

This review summarizes the current state of research on the unique chemical reaction of converting proteins into DNA mimetics by lipid peroxidation, and discusses the electrochemical properties and recognition characteristics of pyrrolated proteins.