Selenium and selenoproteins in thermogenic adipocytes

Selenium (Se) is involved in energy metabolism in the liver, white adipose tissue, and skeletal muscle, and may also play a role in thermogenic adipocytes, i.e. brown and beige adipocytes. Thereby this micronutrient is a key nutritional target to aid in combating obesity and metabolic diseases. In thermogenic adipocytes, particularly in brown adipose tissue (BAT), the selenoprotein type 2 iodothyronine deiodinase (DIO2) is essential for the activation of adaptive thermogenesis. Recent evidence has suggested that additional selenoproteins may also be participating in this process, and a role for Se itself through its metabolic pathways is also envisioned. In this review, we discuss the recognized effects and the knowledge gaps in the involvement of Se metabolism and selenoproteins in the mechanisms of adaptive thermogenesis in thermogenic (brown and beige) adipocytes.

Automated summary

Selenium plays a role in energy metabolism, particularly in brown and beige adipocytes. The selenoprotein DIO2 is crucial for activating adaptive thermogenesis, and other selenoproteins may also be involved. This review discusses the involvement of selenium metabolism and selenoproteins in the mechanisms of adaptive thermogenesis in brown and beige adipocytes, highlighting the gaps in knowledge.