4.6 Article

E6E7 regulates the HK2 expression in cervical cancer via GSK3B/FTO signal

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

HPV E6/E7 promotes aerobic glycolysis in cervical cancer by regulating IGF2BP2 to stabilize m6A-MYC expression

Chenchen Hu et al.

Summary: This study demonstrates that HPV infection enhances aerobic glycolysis in cervical cancer cells through the regulation of MYC mRNA modifications by E6/E7 proteins via IGF2BP2.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

Article Biochemistry & Molecular Biology

Comprehensive Analysis of N6-Methyladenosine (m6A) Writers, Erasers, and Readers in Cervical Cancer

Mateja Condic et al.

Summary: There is growing evidence for the important role of post-transcriptional RNA modifications in cancer development and progression. This study examined the expression levels of m6A writers, readers, and erasers in cervical cancer cohorts and found that high protein expression levels of certain factors were associated with shorter overall survival. m6A may serve as a promising prognostic biomarker and therapeutic target in cervical cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Cell Biology

Kinase GSK3β functions as a suppressor in colorectal carcinoma through the FTO-mediated MZF1/c-Myc axis

Zeyan Zhang et al.

Summary: The study found that GSK3 beta suppresses the progression of CRC through the FTO-regulated MZF1/c-Myc axis, providing a new possible pathway for CRC treatment.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Environmental Sciences

G2 and S phase-expressed-1 acts as a putative tumor promoter in cervical cancer by enhancing Wnt/β-catenin signaling via modulation of GSK-3β

Wenting Guo et al.

Summary: This study shows that GTSE1 is overexpressed in cervical cancer and its suppression inhibits tumor growth by down-regulating Wnt/β-catenin signaling pathway. GTSE1 knockdown reduces cell proliferation and invasion abilities in cervical cancer cells, and impedes in vivo tumorigenicity.

ENVIRONMENTAL TOXICOLOGY (2021)

Article Oncology

Constructe a novel 5 hypoxia genes signature for cervical cancer

Yang Yang et al.

Summary: This study presented a 5-gene signature prognostic system based on the hypoxic pathway of cervical cancer, which can independently evaluate the prognostic risk of patients and has been experimentally validated. These signature genes can regulate the biological functions of cervical cancer cells, providing potential targets for the treatment of cervical cancer patients.

CANCER CELL INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

m6A-dependent glycolysis enhances colorectal cancer progression

Chaoqin Shen et al.

MOLECULAR CANCER (2020)

Review Cell Biology

Glycogen Synthase Kinase 3β in Cancer Biology and Treatment

Takahiro Domoto et al.

CELLS (2020)

Editorial Material Medicine, General & Internal

Cervical Cancer Screening More Choices in 2019

George F. Sawaya et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Review Biochemistry & Molecular Biology

The role of m6A RNA methylation in human cancer

Xiao-Yu Chen et al.

MOLECULAR CANCER (2019)

Article Oncology

The Roles of HK2 on Tumorigenesis of Cervical Cancer

Chunyan Liu et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2019)

Article Biochemistry & Molecular Biology

Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells

Kelsie J. Faulds et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets

Karin Hoppe-Seyler et al.

TRENDS IN MICROBIOLOGY (2018)

Article Oncology

Worldwide burden of cancer attributable to HPV by site, country and HPV type

Catherine de Martel et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

Review Cell Biology

Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases

Romina Mancinelli et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Article Multidisciplinary Sciences

Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy

Aleksander Aas et al.

PLOS ONE (2017)

Review Oncology

Cervical Cancer: A Global Health Crisis

William Small et al.

CANCER (2017)

Article Multidisciplinary Sciences

Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex

Xiang Wang et al.

NATURE (2016)

Article Multidisciplinary Sciences

GSK3β mediates the carcinogenic effect of HPV16 in cervical cancer

Cuiling Ma et al.

SCIENTIFIC REPORTS (2015)

Article Biochemistry & Molecular Biology

Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition

David J. Roberts et al.

MOLECULAR CELL (2014)

Article Multidisciplinary Sciences

N6-methyladenosine-dependent regulation of messenger RNA stability

Xiao Wang et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

Guanqun Zheng et al.

MOLECULAR CELL (2013)

Article Oncology

GSK-3 Promotes Cell Survival, Growth, and PAX3 Levels in Human Melanoma Cells

Jennifer D. Kubic et al.

MOLECULAR CANCER RESEARCH (2012)

Article Obstetrics & Gynecology

Cetuximab monotherapy in advanced cervical cancer: a retrospective study with five patients

Linda Hertlein et al.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2011)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Biochemistry & Molecular Biology

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Guifang Jia et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Oncology

A study of association between expression of hOGG1, VDAC1, HK-2 and cervical carcinoma

Peng Guo-Qing et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2010)

Article Multidisciplinary Sciences

Crystal structure of the FTO protein reveals basis for its substrate specificity

Zhifu Han et al.

NATURE (2010)

Article Genetics & Heredity

Variation in FTO contributes to childhood obesity and severe adult obesity

Christian Dina et al.

NATURE GENETICS (2007)