Journal
JOURNAL OF HEALTH ECONOMICS
Volume 45, Issue -, Pages 131-148Publisher
ELSEVIER
DOI: 10.1016/j.jhealeco.2015.10.007
Keywords
ALSPAC; Genetic variants; Instrumental variables; Mendelian randomization; Potential outcomes
Funding
- Economic and Social Research Council [RES-060-23-0011, PTA-026-27-2335]
- MRC [G0601625, G1002345]
- European Research Council [269874-DEVHEALTH]
- ESRC [ES/H005803/1] Funding Source: UKRI
- MRC [MC_UU_12013/5, MC_UU_12013/1, MC_UU_12013/9] Funding Source: UKRI
- Economic and Social Research Council [ES/H005803/1, RES-343-28-3001] Funding Source: researchfish
- Medical Research Council [MC_UU_12013/5, MC_UU_12013/9, G1002345, G0601625, MC_UU_12013/1, MC_PC_15018] Funding Source: researchfish
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The use of genetic markers as instrumental variables (IV) is receiving increasing attention from economists, statisticians, epidemiologists and social scientists. Although IV is commonly used in economics, the appropriate conditions for the use of genetic variants as instruments have not been well defined. The increasing availability of biomedical data, however, makes understanding of these conditions crucial to the successful use of genotypes as instruments. We combine the econometric IV literature with that from genetic epidemiology, and discuss the biological conditions and IV assumptions within the statistical potential outcomes framework. We review this in the context of two illustrative applications. (C) 2015 The Authors. Published by Elsevier B.V.
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