Journal
APPLIED PHYSICS EXPRESS
Volume 15, Issue 10, Pages -Publisher
IOP Publishing Ltd
DOI: 10.35848/1882-0786/ac9453
Keywords
microneedle; biodegradable polymer; microfabrication
Categories
Funding
- Japan Agency for Medical Research and Development (AMED) [JP22he0422015]
- Center of Innovation Program (COI STREAM) from Japan Science and Technology Agency (JST)
- Nanotechnology Platform Program of the Ministry of Education, Culture, Sports, Science and Technology [JPMXP09F20UT0026]
- [21J14930]
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This study investigated the deformation behavior of poly(L-lactic acid) microneedles with different tip diameters through simulation and experiment. It was found that the plastic deformation of the tip may increase the insertion force.
To explore minimally invasive and hypodermic access for in-body sensing, polymer microneedles of 2 mm in length have been studied. Sharper tips are desirable to reduce pain, however, the mechanical strength of such tips is low. To design polymer microneedles that do not plastically deform, the deformation behavior of poly(L-lactic acid) microneedles with different tip diameters was investigated by simulation and experiment. It was found that the plastic deformation of the tip may increase the insertion force. The minimum insertion force was approximately 200 mN for microneedles with a tip diameter of 80 mu m, which were inserted without plastic deformation.
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