Robust parameter identification of a nonlinear impulsive time-delay system in microbial fed-batch process

In this paper, taking the feeding process as an impulsive form and considering the timedelay in fermentation process, we propose a nonlinear impulsive time-delay system to formulate the fed-batch culture in microbial 1,3-propanediol production. For this system, we discuss some important properties of the solution. To determine the optimal time-delay and kinetic parameters in the system, we then present a robust parameter identification model subject to continuous state inequality constraints. By the constraint transcription technique and a penalty method, we transform the robust parameter identification problem to a sequence of optimization problems with only box constraints. On this basis, we propose a parallel Particle Swarm Optimization algorithm to solve the resulting problem. Finally, the numerical results show that the impulsive time-delay system can well describe the fed-batch process and the developed algorithm is highly effective. (c) 2022 Elsevier Inc. All rights reserved.

Automated summary

This study presents a nonlinear impulsive time-delay system to describe the fed-batch culture in microbial 1,3-propanediol production, discusses important properties of the solution, and proposes a robust parameter identification model and solution. Numerical results indicate that both the system and algorithm perform well.