Related references
Note: Only part of the references are listed.A yellow fever virus NS4B inhibitor not only suppresses viral replication, but also enhances the virus activation of RIG-I-like receptor-mediated innate immune response
Zhao Gao et al.
PLOS PATHOGENS (2022)
Flavivirus recruits the valosin-containing protein-NPL4 complex to induce stress granule disassembly for efficient viral genome replication
Masashi Arakawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2022)
Corona versus Dengue: Distinct Mechanisms for Inhibition of Polyprotein Processing by Antiviral Drugs
Mira A. M. Behnam et al.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2022)
TMEM41B Is a Pan-flavivirus Host Factor
H. Heinrich Hoffmann et al.
CELL (2021)
On track to tackle dengue: History and future of NS4B ligands
Mira A. M. Behnam et al.
CELL HOST & MICROBE (2021)
Novel insights into the function of an N-terminal region of DENV2 NS4B for the optimal helicase activity of NS3
Hongyun Lu et al.
VIRUS RESEARCH (2021)
A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction
Suzanne J. F. Kaptein et al.
NATURE (2021)
Zika Virus Infection Induced Apoptosis by Modulating the Recruitment and Activation of Proapoptotic Protein Bax
Xiaodong Han et al.
JOURNAL OF VIROLOGY (2021)
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models
Stephanie A. Moquin et al.
SCIENCE TRANSLATIONAL MEDICINE (2021)
INMI1 Zika Virus NS4B Antagonizes the Interferon Signaling by Suppressing STAT1 Phosphorylation
Elisa Fanunza et al.
VIRUSES-BASEL (2021)
Molecular Insights into the Flavivirus Replication Complex
Kain van den Elsen et al.
VIRUSES-BASEL (2021)
TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2
Joseph D. Trimarco et al.
PLOS PATHOGENS (2021)
Mapping Interactions among Cell-Free Expressed Zika Virus Proteins
Shayli Varasteh Moradi et al.
JOURNAL OF PROTEOME RESEARCH (2020)
The continued threat of emerging flaviviruses
Theodore C. Pierson et al.
NATURE MICROBIOLOGY (2020)
Development of antibody-based assays for high throughput discovery and mechanistic study of antiviral agents against yellow fever virus
Zhao Gao et al.
ANTIVIRAL RESEARCH (2020)
A cocrystal structure of dengue capsid protein in complex of inhibitor
Hongjie Xia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Recent advances in antiviral drug development towards dengue virus
Berit Troost et al.
CURRENT OPINION IN VIROLOGY (2020)
TMEM41B functions with VMP1 in autophagosome formation
Keigo Morita et al.
AUTOPHAGY (2019)
The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection
David L. Lin et al.
CELL REPORTS (2019)
A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle
Anna Plaszczyca et al.
PLOS PATHOGENS (2019)
The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins
Ashley M. Ngo et al.
ELIFE (2019)
Dengue NS2A Protein Orchestrates Virus Assembly
Xuping Xie et al.
CELL HOST & MICROBE (2019)
An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses
Guangyu Li et al.
NPJ VACCINES (2019)
Dengue virus NS2 and NS4: Minor proteins, mammoth roles
Sindhoora Bhargavi Gopala Reddy et al.
BIOCHEMICAL PHARMACOLOGY (2018)
A single amino acid substitution in the NS4B protein of Dengue virus confers enhanced virus growth and fitness in human cells in vitro through IFN-dependent host response
Thuy Thu Bui et al.
JOURNAL OF GENERAL VIROLOGY (2018)
Yellow Fever Virus: Knowledge Gaps Impeding the Fight Against an Old Foe
Florian Douam et al.
TRENDS IN MICROBIOLOGY (2018)
K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B
Maria Isabel Giraldo et al.
VIRUS RESEARCH (2018)
TMEM41B is a novel regulator of autophagy and lipid mobilization
Francesca Moretti et al.
EMBO REPORTS (2018)
An orthogonal proteomic survey uncovers novel Zika virus host factors
Pietro Scaturro et al.
NATURE (2018)
Genomic and epidemiological monitoring of yellow fever virus transmission potential
N. R. Faria et al.
SCIENCE (2018)
Systems Biology Reveals NS4B-Cyclophilin A Interaction: A New Target to Inhibit YFV Replication
Alessandra Vidotto et al.
JOURNAL OF PROTEOME RESEARCH (2017)
Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond
Veaceslav Boldescu et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex
David L. Lin et al.
MBIO (2017)
A Global Interactome Map of the Dengue Virus NS1 Identifies Virus Restriction and Dependency Host Factors
Mohamed Lamine Hafirassou et al.
CELL REPORTS (2017)
New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach
Eduardo Esteves et al.
BIOMED RESEARCH INTERNATIONAL (2017)
Progress and Works in Progress: Update on Flavivirus Vaccine Development
Matthew H. Collins et al.
CLINICAL THERAPEUTICS (2017)
Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses
Laurent Chatel-Chaix et al.
CELL HOST & MICROBE (2016)
Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy
Qiming Liang et al.
CELL STEM CELL (2016)
A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection by Specifically Targeting NS4B Protein
Fang Guo et al.
JOURNAL OF VIROLOGY (2016)
Transmembrane Domains of NS2B Contribute to both Viral RNA Replication and Particle Formation in Japanese Encephalitis Virus
Xiao-Dan Li et al.
JOURNAL OF VIROLOGY (2016)
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses
Rong Zhang et al.
NATURE (2016)
Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
Caleb D. Marceau et al.
NATURE (2016)
Zika Virus Associated with Microcephaly
Jernej Mlakar et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics
George Savidis et al.
CELL REPORTS (2016)
The Impact of the Newly Licensed Dengue Vaccine in Endemic Countries
Maira Aguiar et al.
PLOS NEGLECTED TROPICAL DISEASES (2016)
Targeting dengue virus NS4B protein for drug discovery
Xuping Xie et al.
ANTIVIRAL RESEARCH (2015)
The dengue virus NS5 protein as a target for drug discovery
Siew Pheng Lim et al.
ANTIVIRAL RESEARCH (2015)
The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development
Dahai Luo et al.
ANTIVIRAL RESEARCH (2015)
Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids
Yan Li et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2015)
Post-translational regulation and modifications of flavivirus structural proteins
Justin A. Roby et al.
JOURNAL OF GENERAL VIROLOGY (2015)
Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus
Xiao-Dan Li et al.
JOURNAL OF GENERAL VIROLOGY (2015)
Discovery of Dengue Virus NS4B Inhibitors
Qing-Yin Wang et al.
JOURNAL OF VIROLOGY (2015)
A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication
Laurent Chatel-Chaix et al.
JOURNAL OF VIROLOGY (2015)
Mutation of Putative N-Glycosylation Sites on Dengue Virus NS4B Decreases RNA Replication
Nenavath Gopal Naik et al.
JOURNAL OF VIROLOGY (2015)
Mapping the Interactions between the NS4B and NS3 Proteins of Dengue Virus
Jing Zou et al.
JOURNAL OF VIROLOGY (2015)
Characterization of Dengue Virus NS4A and NS4B Protein Interaction
Jing Zou et al.
JOURNAL OF VIROLOGY (2015)
Determinants of Dengue Virus NS4A Protein Oligomerization
Chia Min Lee et al.
JOURNAL OF VIROLOGY (2015)
Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention
Joanna Zmurko et al.
REVIEWS IN MEDICAL VIROLOGY (2015)
Flaviviral Replication Complex: Coordination between RNA Synthesis and 5′-RNA Capping
Valerie J. Klema et al.
VIRUSES-BASEL (2015)
Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors
Bin Zou et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Induction of Endoplasmic Reticulum-Derived Replication-Competent Membrane Structures by West Nile Virus Non-Structural Protein 4B
Pakieli H. Kaufusi et al.
PLOS ONE (2014)
A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available
Tomohiro Ishikawa et al.
VACCINE (2014)
The flavivirus NS1 protein: Molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker
David A. Muller et al.
ANTIVIRAL RESEARCH (2013)
Role of RNA Interference (RNAi) in Dengue Virus Replication and Identification of NS4B as an RNAi Suppressor
Pavan Kumar Kakumani et al.
JOURNAL OF VIROLOGY (2013)
Membrane Topology and Function of Dengue Virus NS2A Protein
Xuping Xie et al.
JOURNAL OF VIROLOGY (2013)
An N-Terminal Amphipathic Helix in Dengue Virus Nonstructural Protein 4A Mediates Oligomerization and Is Essential for Replication
Omer Stern et al.
JOURNAL OF VIROLOGY (2013)
The global distribution and burden of dengue
Samir Bhatt et al.
NATURE (2013)
Protein-protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells
Li Yu et al.
VIROLOGY (2013)
Evidence for a Genetic and Physical Interaction between Nonstructural Proteins NS1 and NS4B That Modulates Replication of West Nile Virus
Soonjeon Youn et al.
JOURNAL OF VIROLOGY (2012)
West Nile Virus Infections Suppress Early Viral RNA Synthesis and Avoid Inducing the Cell Stress Granule Response
S. C. Courtney et al.
JOURNAL OF VIROLOGY (2012)
Mutational analysis of the West Nile virus NS4B protein
Jason A. Wicker et al.
VIROLOGY (2012)
Restoration of replication-defective dengue type 1 virus bearing mutations in the N-terminal cytoplasmic portion of NS4A by additional mutations in NS4B
Shigeru Tajima et al.
ARCHIVES OF VIROLOGY (2011)
Flavivirus NS4A-induced Autophagy Protects Cells against Death and Enhances Virus Replication
Jeffrey E. McLean et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Inhibition of Dengue Virus by Targeting Viral NS4B Protein
Xuping Xie et al.
JOURNAL OF VIROLOGY (2011)
Immune responses to an attenuated West Nile virus NS4B-P38G mutant strain
Thomas Welte et al.
VACCINE (2011)
Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccine
Anna P. Durbin et al.
VACCINE (2011)
Structure and functionality in flavivirus NS-proteins: Perspectives for drug design
Michela Bollati et al.
ANTIVIRAL RESEARCH (2010)
Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay
Chinmay G. Patkar et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Molecular targets for flavivirus drug discovery
Aruna Sampath et al.
ANTIVIRAL RESEARCH (2009)
Role of nonstructural protein NS2A in flavivirus assembly
Jason Y. Leung et al.
JOURNAL OF VIROLOGY (2008)
Prospects for a dengue virus vaccine
Stephen S. Whitehead et al.
NATURE REVIEWS MICROBIOLOGY (2007)
Structure and function of flavivirus NS5 methyltransferase
Yangsheng Zhou et al.
JOURNAL OF VIROLOGY (2007)
The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner
Sven Miller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
West nile virus 5′-cap structure is formed by sequential guanine N-7 and ribose 2′-O methylations by nonstructural protein 5
Debashish Ray et al.
JOURNAL OF VIROLOGY (2006)
Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA
Indira Umareddy et al.
JOURNAL OF GENERAL VIROLOGY (2006)
Subcellular localization and membrane topology of the dengue virus type 2 non-structural protein 4B
S Miller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses
JL Muñoz-Jordán et al.
JOURNAL OF VIROLOGY (2005)
Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins
WJ Liu et al.
JOURNAL OF VIROLOGY (2005)
A structural perspective of the Flavivirus life cycle
S Mukhopadhyay et al.
NATURE REVIEWS MICROBIOLOGY (2005)
Inhibition of interferon signaling by dengue virus
JL Muñoz-Jordán et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
An RNA cap (nucleoside-2′-O-)-methyltransferase in the flavivirus RNA polymerase NS5:: crystal structure and functional characterization
MP Egloff et al.
EMBO JOURNAL (2002)