Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 66, Issue 9, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/aac.02318-21
Keywords
gonorrhoea; Neisseria gonorrhoeae; Neisseria meningitidis; PBT2; antibiotic resistance; ionophore
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Funding
- Australian National Health and Medical Research Council (NHMRC) [1071659, 1138466, 1176180, 1196520, 1194130, 2001210]
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The ionophore PBT2, when used alone, has shown potential in killing both N.meningitidis and MDR N. gonorrhoeae, making it a candidate therapy for MDR N. gonorrhoeae infections.
Multidrug-resistant (MDR) N. gonorrhoeae is a current public health threat. New therapies are urgently needed. PBT2 is an ionophore that disrupts metal homeostasis. PBT2 administered with zinc is shown to reverse resistance to antibiotics in several bacterial pathogens. Here we show that both N. meningitidis and MDR N. gonorrhoeae are sensitive to killing by PBT2 alone. PBT2 is, thus, a candidate therapeutic for MDR N. gonorrhoeae infections.
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