4.5 Review

Adipose Tissue Remodeling in Pathophysiology

Related references

Note: Only part of the references are listed.
Article Dermatology

Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation

Carina Nicu et al.

Summary: The study reveals that dermal white adipose tissue regulates human hair growth and pigmentation through the secretion of HGF, identifying dWAT and HGF as important novel molecular and cellular targets for therapeutic intervention in human hair growth and pigmentation disorders.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Article Multidisciplinary Sciences

Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides

Kristyna Brejchova et al.

Summary: Branched esters of palmitic acid and hydroxy stearic acid, known as FAHFAs, are anti-inflammatory and antidiabetic lipokines. Two major metabolic lipases, ATGL and HSL, play distinct roles in the degradation of TAG estolides and FAHFAs. ATGL liberates FAHFAs preferentially from more compact substrates, while HSL acts as a potent estolide bond hydrolase for both TAG estolides and free FAHFAs.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Physiology

Cellular Heterogeneity in Adipose Tissues

Silvia Corvera

Summary: Adipose tissue consists of heterogeneous cell populations, including mature adipocytes, progenitors, endothelial cells, and various immune cell types, which work together to regulate tissue development and functions. Recent advances in genetic lineage tracing and transcriptomics have revealed new insights into the roles of progenitor subtypes and monocytes/macrophages in adipose tissue metabolism and metabolic disease. These studies provide valuable data for exploring similarities and differences among experimental models and enhancing our understanding of the complex mechanisms of adipose tissues.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 83 (2021)

Article Cell & Tissue Engineering

Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

Mengle Shao et al.

Summary: Regional differences in adipose precursor cells' response to obesity are driven by HIF alpha-induced PDGFR beta signaling, leading to inhibitory phosphorylation of PPAR gamma. Suppression of HIF alpha promotes adipogenesis and improves metabolic health in obesity, with potential for pharmacological targeting of APCs to enhance metabolic health.

CELL STEM CELL (2021)

Article Multidisciplinary Sciences

Creatine kinase B controls futile creatine cycling in thermogenic fat

Janane F. Rahbani et al.

Summary: The research highlights the impact of obesity on mortality risk due to metabolic sequelae and the role of thermogenesis by adipocytes in combating obesity and metabolic diseases. It identifies creatine kinase B (CKB) as a key player in the futile creatine cycle, crucial for thermogenesis in adipose tissues, and its induction by thermogenic stimuli. The study in mice shows that adipocyte-selective inactivation of CKB reduces thermogenic capacity, increases susceptibility to obesity, and disrupts glucose homeostasis.

NATURE (2021)

Article Critical Care Medicine

Thermal Stress Induces Long-Term Remodeling of Adipose Tissue and Is Associated with Systemic Dysfunction

Carly M. Knuth et al.

Summary: Severe burns lead to a futile cycle of lipolysis and white adipose tissue browning, resulting in fat catabolism, hepatomegaly, and weight loss despite increased food intake. Therapeutic interventions targeting the physiological changes in adipose depots can improve outcomes post-burn. These findings may have implications for treating conditions like cancer cachexia, as well as developing treatments for obesity and type II diabetes.

SHOCK (2021)

Review Physiology

Angiogenesis in Adipose Tissue: The Interplay Between Adipose and Endothelial Cells

Jacqueline Herold et al.

Summary: Obesity leads to expansion of adipose tissue, affecting its angiogenic capacity and increasing the risk of obesity-related diseases such as cardiovascular diseases.

FRONTIERS IN PHYSIOLOGY (2021)

Article Cell Biology

Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis

Hai P. Nguyen et al.

Summary: Adipose tissue mass and adiposity change throughout lifespan, with visceral adipose tissue (VAT) increasing and subcutaneous adipose tissue (SAT) decreasing with aging. A regulatory cell population called ARCs emerges in aging SAT, expressing progenitor markers but lacking adipogenic capacity, inhibiting proliferation and differentiation of neighboring adipose precursors. Pu.1 is identified as a driving factor for ARC development, correlating with aging-associated loss of SAT.

DEVELOPMENTAL CELL (2021)

Article Biochemistry & Molecular Biology

Interleukin-6 blockade, a potential adjunct therapy for post-burn hypermetabolism

Dalia Barayan et al.

Summary: Severe burns can lead to hypermetabolism, but blocking IL-6 can effectively alleviate complications and improve survival rates. The study demonstrates the potential of anti-IL-6 interventions in improving care and quality of life in burned patients.

FASEB JOURNAL (2021)

Article Multidisciplinary Sciences

Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine

Yizhi Sun et al.

Summary: Adaptive thermogenesis, through the futile cycling of creatine in thermogenic fat cells, plays a critical role in increasing energy expenditure. Phosphocreatine phosphatase activity attributed to tissue-nonspecific alkaline phosphatase (TNAP) is essential for this process.

NATURE (2021)

Article Immunology

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

Andrew D. Hildreth et al.

Summary: This study provides a comprehensive analysis of the cellular composition in healthy and obese human white adipose tissue, revealing changes in immune cell populations and inflammatory pathways in obese individuals. The findings highlight the importance of immune cell regulation in metabolic diseases and offer insights into new cellular networks and differentiation trajectories in white adipose tissue.

NATURE IMMUNOLOGY (2021)

Review Cell Biology

The cellular and functional complexity of thermogenic fat

Paul Cohen et al.

Summary: Brown and beige adipocytes are mitochondria-enriched cells that can dissipate energy in the form of heat, regulating whole-body energy metabolism. They have diverse functions beyond thermogenesis, acting as metabolite sinks, secretory cells, and regulators of adipose tissue homeostasis, ultimately contributing to improved metabolic health.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Review Endocrinology & Metabolism

Signaling Pathways Regulating Thermogenesis

Chihiro Tabuchi et al.

Summary: Obesity, a global epidemic, lacks safe and effective therapeutic agents. Recent studies have shown the presence of brown or brown-like adipocytes in adult humans, with potential therapeutic implications for combating obesity. The main signaling pathway to activate thermogenesis in adipocytes is the beta-adrenergic pathway.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Endocrinology & Metabolism

Obesity protects against sepsis-induced and norepinephrine-induced white adipose tissue browning

Cheryl Li et al.

Summary: White adipose tissue browning is detrimental in patients with burn injury and cancer. WAT browning occurs in nonobese mice and can be induced by beta receptor norepinephrine infusion, but obese mice are resistant to sepsis-induced and norepinephrine-induced WAT browning. Obese mice may be protected from sepsis due to the lack of WAT browning and unchanged inflammatory cytokine response.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021)

Article Biochemistry & Molecular Biology

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Olivia Sveidahl Johansen et al.

Summary: Researchers have discovered that the constitutively active receptor GPR3, through its N terminus signaling activity, induces continuous cAMP production in adipose tissue, leading to thermogenesis. Increasing GPR3 expression in thermogenic adipocytes alone is sufficient to drive energy expenditure and counteract metabolic disease.
Article Cell Biology

Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin

Jesper Baeckdahl et al.

Summary: By studying the composition and structure of WAT, we identified that human WAT is composed of three classes of mature adipocytes, only one of which is insulin responsive.

CELL METABOLISM (2021)

Article Cell Biology

The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy

Gang Wei et al.

Summary: Clear cell renal cell carcinoma preferentially invades perinephric adipose tissue (PAT), with a bi-directional communication between ccRCC cells and PAT described in this study. The secretion of PTHrP by ccRCC cells promotes PAT browning, while PAT-mediated thermogenesis enhances ccRCC growth and metastasis. Tyrosine kinase inhibitors (TKIs) used in ccRCC treatment can exacerbate this vicious cycle, but pharmacological suppression of adipocyte browning can enhance the anti-tumor efficacy of TKI sunitinib.

CELL METABOLISM (2021)

Article Cell Biology

Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2

Moritz Reiterer et al.

Summary: The study found that hyperglycemia is common among patients with ARDS, and in patients with both ARDS and COVID-19, insulin resistance is the main cause of hyperglycemia. COVID-19 patients have lower levels of adiponectin, and SARS-CoV-2 may infect adipocytes, leading to dysfunction of adipose tissue.

CELL METABOLISM (2021)

Article Multidisciplinary Sciences

A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke

Toshiko Yamazawa et al.

Summary: The study shows that an oxolinic acid-derivative RyR1 inhibitor can effectively prevent and treat various malignant hyperthermia (MH) and heat stroke mouse models.

NATURE COMMUNICATIONS (2021)

Article Microbiology

Trypanosoma brucei triggers a broad immune response in the adipose tissue

Henrique Machado et al.

Summary: The adipose tissue responds immunologically to Trypanosoma brucei infection, displaying upregulation of genes related to inflammation and immune cell functions. Macrophages, neutrophils, CD4+ and CD8+ T lymphocytes infiltrate the tissue upon infection, with an accumulation of antigen-specific antibodies as infection progresses. The adaptive immune system plays a key role in controlling parasite load in both the bloodstream and adipose tissue.

PLOS PATHOGENS (2021)

Article Biology

Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

Laura Le Pelletier et al.

Summary: As individuals age, adipose-derived stromal cells (ASCs) exhibit distinct characteristics, with in vitro aging experiments showing the presence of senescence and oxidative stress.

ELIFE (2021)

Article Medicine, Research & Experimental

Adipose browning response to burn trauma is impaired with aging

Abdikarim Abdullahi et al.

Summary: Older burn patients lack adipose tissue browning response, leading to reduced overall metabolism and lower survival rates. The study suggests that the adipose tissue of traumatized older patients is impaired and lacks key immunological regulators, indicating potential targets for therapeutic interventions.

JCI INSIGHT (2021)

Article Oncology

Adipose-specific ATGL ablation reduces burn injury-induced metabolic derangements in mice

Supreet Kaur et al.

Summary: Hypermetabolism following severe burn injuries can lead to adipocyte dysfunction and other adverse consequences, with adipose triglyceride lipase (ATGL) playing a crucial role in regulating these processes. Targeting ATGL may reduce adipose tissue changes and improve patient outcomes, as demonstrated by selective ATGL inhibitor studies.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Cell Biology

Brown adipose tissue is associated with healthier body fat distribution and metabolic benefits independent of regional adiposity

Andreas G. Wibmer et al.

Summary: The study found that brown adipose tissue (BAT) is associated with lower visceral adipose tissue and higher subcutaneous adipose tissue, which helps reduce central obesity. Additionally, BAT is independently linked to lower blood glucose, improved lipids, and a lower prevalence of type 2 diabetes.

CELL REPORTS MEDICINE (2021)

Article Endocrinology & Metabolism

Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes

Farnaz Shamsi et al.

Summary: Vascular smooth muscle cells expressing Trpv1 are identified as previously unrecognized thermogenic adipocyte progenitors, playing a role in the expansion and differentiation of highly thermogenic adipocytes in response to cold stimuli.

NATURE METABOLISM (2021)

Article Endocrinology & Metabolism

No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians

Niels J. Connell et al.

Summary: The study found that creatine monohydrate supplementation does not enhance BAT activation after acute cold exposure in young, healthy, lean, vegetarian adults.

NATURE METABOLISM (2021)

Article Medicine, Research & Experimental

Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue

Anying Song et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Cell & Tissue Engineering

Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

Brett A. Shook et al.

CELL STEM CELL (2020)

Article Cardiac & Cardiovascular Systems

Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity

Ada Weinstock et al.

CIRCULATION RESEARCH (2020)

Article Medicine, General & Internal

Gastrointestinal pain

Asbjorn M. Drewes et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Article Medicine, Research & Experimental

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans

Brian S. Finlin et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Medicine, Research & Experimental

Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity

Alana E. O'Mara et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Multidisciplinary Sciences

Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis

Kazuki Tajima et al.

NATURE COMMUNICATIONS (2020)

Article Critical Care Medicine

Sepsis and the Obesity Paradox: Size Matters in More Than One Way

Nikhil Jagan et al.

CRITICAL CARE MEDICINE (2020)

Article Biochemistry & Molecular Biology

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

Yasuo Oguri et al.

Review Biochemistry & Molecular Biology

The Impact of Single-Cell Genomics on Adipose Tissue Research

Alana Deutsch et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

Tadashi Yamamuro et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

Hui J. Wang et al.

NATURE COMMUNICATIONS (2020)

Review Cell Biology

Adipose Tissue Metabolic Function and Dysfunction: Impact of Burn Injury

Supreet Kaur et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Multidisciplinary Sciences

snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis

Wenfei Sun et al.

NATURE (2020)

Article Endocrinology & Metabolism

Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types

Jinchu Vijay et al.

NATURE METABOLISM (2020)

Article Surgery

Alternatively Activated Macrophages Drive Browning of White Adipose Tissue in Burns

Abdikarim Abdullahi et al.

ANNALS OF SURGERY (2019)

Review Dermatology

Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense

Stella X. Chen et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

Article Multidisciplinary Sciences

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

David Merrick et al.

SCIENCE (2019)

Article Microbiology

Adipose Tissue Regulates Pulmonary Pathology during TB Infection

Janeesh Plakkal Ayyappan et al.

Article Cell Biology

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate

Wenshan Wang et al.

CELL METABOLISM (2019)

Article Medicine, General & Internal

mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis

Nuria Martinez et al.

EBIOMEDICINE (2019)

Review Medicine, Research & Experimental

What lipodystrophies teach us about the metabolic syndrome

Jake P. Mann et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Medicine, Research & Experimental

TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding

Can Liu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

Article Medicine, Research & Experimental

Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

Zhuzhen Zhang et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Cell Biology

Browning of white adipose tissue after a burn injury promotes hepatic steatosis and dysfunction

Abdikarim Abdullahi et al.

CELL DEATH & DISEASE (2019)

Article Endocrinology & Metabolism

Mefformin prevents the pathological browning of subcutaneous white adipose tissue

Christopher Auger et al.

MOLECULAR METABOLISM (2019)

Review Cell Biology

New Advances in Adaptive Thermogenesis: UCP1 and Beyond

Edward T. Chouchani et al.

CELL METABOLISM (2019)

Article Multidisciplinary Sciences

Thermal stress induces glycolytic beige fat formation via a myogenic state

Yong Chen et al.

NATURE (2019)

Article Endocrinology & Metabolism

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

Lawrence Kazak et al.

NATURE METABOLISM (2019)

Review Endocrinology & Metabolism

Metabolic adaptation and maladaptation in adipose tissue

Edward T. Chouchani et al.

NATURE METABOLISM (2019)

Article Critical Care Medicine

SEPSIS INDUCES ADIPOSE TISSUE BROWNING IN NONOBESE MICE BUT NOT IN OBESE MICE

Itay Ayalon et al.

SHOCK (2018)

Article Biochemistry & Molecular Biology

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

Xiaodan Lu et al.

SCIENCE SIGNALING (2018)

Article Multidisciplinary Sciences

Metformin adapts its cellular effects to bioenergetic status in a model of metabolic dysfunction

Christopher Auger et al.

SCIENTIFIC REPORTS (2018)

Review Nutrition & Dietetics

The Obesity Paradox in Cancer: How Important Is Muscle?

Elizabeth M. Cespedes Feliciano et al.

ANNUAL REVIEW OF NUTRITION, VOL 38 (2018)

Article Biochemistry & Molecular Biology

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

Xiaodan Lu et al.

SCIENCE SIGNALING (2018)

Article Developmental Biology

A mesodermal fate map for adipose tissue

Zachary L. Sebo et al.

DEVELOPMENT (2018)

Article Multidisciplinary Sciences

A stromal cell population that inhibits adipogenesis in mammalian fat depots

Petra C. Schwalie et al.

NATURE (2018)

Review Medicine, Research & Experimental

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

Clair Crewe et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Review Endocrinology & Metabolism

Adapting to obesity with adipose tissue inflammation

Shannon M. Reilly et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

Review Neurosciences

Integration of optogenetics with complementary methodologies in systems neuroscience

Christina K. Kim et al.

NATURE REVIEWS NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades

Michael J. Gaudry et al.

SCIENCE ADVANCES (2017)

Review Biochemistry & Molecular Biology

The biochemical alterations underlying post-burn hypermetabolism

Christopher Auger et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Article Microbiology

Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

Sandra Trindade et al.

CELL HOST & MICROBE (2016)

Article Cell Biology

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance

Svetlana Altshuler-Keylin et al.

CELL METABOLISM (2016)

Article Multidisciplinary Sciences

Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles

Yuan Xue et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function

Daniel C. Berry et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

Lawrence Kazak et al.

Editorial Material Cell Biology

Metformin Action: Concentrations Matter

Ling He et al.

CELL METABOLISM (2015)

Review Cell Biology

Brown and Beige Fat: Physiological Roles beyond Heat Generation

Shingo Kajimura et al.

CELL METABOLISM (2015)

Article Cell Biology

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

Labros S. Sidossis et al.

CELL METABOLISM (2015)

Article Surgery

Fat Grafting for Treatment of Burns, Burn Scars, and Other Difficult Wounds

Nelson Sarto Piccolo et al.

CLINICS IN PLASTIC SURGERY (2015)

Review Medicine, Research & Experimental

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

Labros Sidossis et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Biochemistry & Molecular Biology

Dermal white adipose tissue: a new component of the thermogenic response

Caroline M. Alexander et al.

JOURNAL OF LIPID RESEARCH (2015)

Review Endocrinology & Metabolism

Congenital generalized lipodystrophies-new insights into metabolic dysfunction

Nivedita Patni et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

Article Multidisciplinary Sciences

Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

Ling-juan Zhang et al.

SCIENCE (2015)

Article Cell Biology

A Smooth Muscle-Like Origin for Beige Adipocytes

Jonathan Z. Long et al.

CELL METABOLISM (2014)

Article Multidisciplinary Sciences

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

Joan Sanchez-Gurmaches et al.

NATURE COMMUNICATIONS (2014)

Editorial Material Geriatrics & Gerontology

Prevalence, incidence and clinical impact of cachexia: facts and numbers-update 2014

Stephan von Haehling et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2014)

Article Endocrinology & Metabolism

Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure

Kai Sun et al.

MOLECULAR METABOLISM (2014)

Article Surgery

Mild Obesity Is Protective After Severe Burn Injury

Marc G. Jeschke et al.

ANNALS OF SURGERY (2013)

Review Physiology

Aging, Cellular Senescence, and Cancer

Judith Campisi

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)

Review Cell Biology

Fibrosis and Adipose Tissue Dysfunction

Kai Sun et al.

CELL METABOLISM (2013)

Article Biochemistry & Molecular Biology

Selective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction

Kai Sun et al.

MOLECULAR AND CELLULAR BIOLOGY (2013)

Article Cell Biology

Characterization of the adipocyte cellular lineage in vivo

Ryan Berry et al.

NATURE CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

Qiong A. Wang et al.

NATURE MEDICINE (2013)

Article Endocrinology & Metabolism

Peripheral fat loss and decline in adipogenesis in older humans

Giuseppe Caso et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2013)

Article Multidisciplinary Sciences

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

Ajit S. Divakaruni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Metformin improves healthspan and lifespan in mice

Alejandro Martin-Montalvo et al.

NATURE COMMUNICATIONS (2013)

Article Cell Biology

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Ffolliott M. Fisher et al.

GENES & DEVELOPMENT (2012)

Review Immunology

Metabolic switching and fuel choice during T-cell differentiation and memory development

Gerritje J. W. van der Windt et al.

IMMUNOLOGICAL REVIEWS (2012)

Article Medicine, Research & Experimental

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

Marica Bordicchia et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Biochemistry & Molecular Biology

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

Naresh C. Bal et al.

NATURE MEDICINE (2012)

Article Multidisciplinary Sciences

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

Suman K. Das et al.

SCIENCE (2011)

Review Cell Biology

Fat tissue, aging, and cellular senescence

Tamara Tchkonia et al.

AGING CELL (2010)

Article Endocrinology & Metabolism

Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation

Michael Spencer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)

Article Critical Care Medicine

Intensive Insulin Therapy in Severely Burned Pediatric Patients A Prospective Randomized Trial

Marc G. Jeschke et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

Article Cell Biology

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

Adem Kalender et al.

CELL METABOLISM (2010)

Article Biotechnology & Applied Microbiology

Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases

Yihai Cao

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Critical Care Medicine

EXTENT AND MAGNITUDE OF CATECHOLAMINE SURGE IN PEDIATRIC BURNED PATIENTS

Gabriela A. Kulp et al.

SHOCK (2010)

Article Biochemistry & Molecular Biology

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

Tayeba Khan et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue

Nils Halberg et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Identification of White Adipocyte Progenitor Cells In Vivo

Matthew S. Rodeheffer et al.

Article Multidisciplinary Sciences

PRDM16 controls a brown fat/skeletal muscle switch

Patrick Seale et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Thermogenic activity of Ca2+-ATPase from skeletal muscle heavy sarcoplasmic reticulum:: The role of ryanodine Ca2+ channel

Ana Paula Arruda et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)

Review Medicine, Research & Experimental

Angiogenesis modulates adipogenesis and obesity

Yihai Cao

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis

H Malhi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Endocrinology & Metabolism

Metabolic Obesity: The Paradox Between Visceral and Subcutaneous Fat

Osama Hamdy et al.

CURRENT DIABETES REVIEWS (2006)

Article Biochemistry & Molecular Biology

The adipocyte as an important target cell for Trypanosoma cruzi infection

TP Combs et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Cardiac & Cardiovascular Systems

Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice

E Bråkenhielm et al.

CIRCULATION RESEARCH (2004)

Article Biochemistry & Molecular Biology

A futile metabolic cycle activated in adipocytes by antidiabetic agents

HP Guan et al.

NATURE MEDICINE (2002)

Article Endocrinology & Metabolism

Accelerated substrate cycling: a new energy-wasting role for leptin in vivo

SP Reidy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2002)

Article Multidisciplinary Sciences

The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest

JRJ Yeh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)